Human LRP1 (Low Density Lipoprotein Receptor Related Protein 1) Sandwich ELISA Kit (STJE0010417) STJE0010417 上海玉博生物科技有限公司

Human LRP1 (Low Density Lipoprotein Receptor Related Protein 1) Sandwich ELISA Kit (STJE0010417)

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产品名称：Human LRP1 (Low Density Lipoprotein Receptor Related Protein 1) Sandwich ELISA Kit (STJE0010417)
产品型号：STJE0010417
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human LRP1 (Low Density Lipoprotein Receptor Related Protein 1) Sandwich ELISA Kit (STJE0010417)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.061ng/mL
Detection Limit:	0.156-10ng/mL
Short Description:	This LRP1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	LRP1
Gene ID:	4035
Uniprot ID:	LRP1_HUMAN
Sample Type:	serum, plasma or other biological fluids.

Tissue Specificity	Most abundant in liver, brain and lung.
Post Translational Modifications	Cleaved into a 85 kDa membrane-spanning subunit (LRP-85) and a 515 kDa large extracellular domain (LRP-515) that remains non-covalently associated. Gamma-secretase-dependent cleavage of LRP-85 releases the intracellular domain from the membrane. The N-terminus is blocked. Phosphorylated on serine and threonine residues. Phosphorylated on tyrosine residues upon stimulation with PDGF. Tyrosine phosphorylation promotes interaction with SHC1.
Function	Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Acts as an LRPAP1 alpha-2-macroglobulin receptor. Acts as TAU/MAPT receptor and controls the endocytosis of TAU/MAPT as well as its subsequent spread. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission. (Microbial infection) Functions as a receptor for Pseudomonas aeruginosa exotoxin A.
Protein Name	Prolow-Density Lipoprotein Receptor-Related Protein 1 Lrp-1 Alpha-2-Macroglobulin Receptor A2mr Apolipoprotein E Receptor Apoer Cd Antigen Cd91 Cleaved Into - Low-Density Lipoprotein Receptor-Related Protein 1 85 Kda Subunit Lrp-85 - Low-Density Lipoprotein Receptor-Related Protein 1 515 Kda Subunit Lrp-515 - Low-Density Lipoprotein Receptor-Related Protein 1 Intracellular Domain Lrpicd
Database Links	Reactome: R-HSA-2168880 Reactome: R-HSA-975634
Cellular Localisation	Low-Density Lipoprotein Receptor-Related Protein 1 85 Kda Subunit: Cell Membrane Single-Pass Type I Membrane Protein Membrane Coated Pit Low-Density Lipoprotein Receptor-Related Protein 1 515 Kda Subunit: Cell Membrane Peripheral Membrane Protein Extracellular Side Low-Density Lipoprotein Receptor-Related Protein 1 Intracellular Domain: Cytoplasm Nucleus After Cleavage The Intracellular Domain (Lrpicd) Is Detected Both In The Cytoplasm And In The Nucleus Golgi Outpost Cytoplasm Cytoskeleton Microtubule Organizing Center Localizes To The Postsynaptic Golgi Apparatus Region Also Named Golgi Outpost Which Shapes Dendrite Morphology By Functioning As Sites Of Acentrosomal Microtubule Nucleation
Alternative ELISA Names	Prolow-Density Lipoprotein Receptor-Related Protein 1 ELISA kit Lrp-1 ELISA kit Alpha-2-Macroglobulin Receptor ELISA kit A2mr ELISA kit Apolipoprotein E Receptor ELISA kit Apoer ELISA kit Cd Antigen Cd91 Cleaved Into - Low-Density Lipoprotein Receptor-Related Protein 1 85 Kda Subunit ELISA kit Lrp-85 - Low-Density Lipoprotein Receptor-Related Protein 1 515 Kda Subunit ELISA kit Lrp-515 - Low-Density Lipoprotein Receptor-Related Protein 1 Intracellular Domain ELISA kit Lrpicd ELISA kit LRP1 ELISA kit A2MR ELISA kit APR ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human LRP1 (Low Density Lipoprotein Receptor Related Protein 1) Sandwich ELISA Kit (STJE0010417)