Anti-CD177 antibody (35-285) (STJ115558) STJ115558 上海玉博生物科技有限公司

Anti-CD177 antibody (35-285) (STJ115558)

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产品名称：Anti-CD177 antibody (35-285) (STJ115558)
产品型号：STJ115558
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CD177 antibody (35-285) (STJ115558)

产品描述

Host:	Rabbit
Applications:	IF
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-CD177 (35-285) is suitable for use in Immunofluorescence research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	IF/ICC 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CD177
Gene ID:	57126
Uniprot ID:	CD177_HUMAN
Immunogen Region:	35-285
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 35-285 of human CD177 (NP_065139.2).
Immunogen Sequence:	VSDLPRQWTPKNTSCDSGLG CQDTLMLIESGPQVSLVLSK GCTEAKDQEPRVTEHRMGPG LSLISYTFVCRQEDFCNNLV NSLPLWAPQPPADPGSLRCP VCLSMEGCLEGTTEEICPKG TTHCYDGLLRLRGGGIFSNL RVQGCMPQPVCNLLNGTQEI GPVGMTENCDMKDFLTCHRG TTIMTHGNLAQEPTDWTTSN TEMCEVGQVCQETLLLLDVG LTSTLVGTKGCSTVGAQNS

Tissue Specificity	Highly expressed in normal bone marrow and weakly expressed in fetal liver. During neutrophil differentiation, expression begins at the metamyelocyte stage and continues throughout the subsequent stages (at protein level). Expressed by a subset of mature neutrophils (at protein level). The percentage of neutrophils expressing CD177 varies across the population. Expressed in granulocytes of patients with polycythemia vera (PV) and with essential thrombocythemia (ET).
Post Translational Modifications	N-glycosylated. A soluble form may also be produced by proteolytic cleavage at the cell surface (shedding).
Function	In association with beta-2 integrin heterodimer ITGAM/CD11b and ITGB2/CD18, mediates activation of TNF-alpha primed neutrophils including degranulation and superoxide production. In addition, by preventing beta-2 integrin internalization and attenuating chemokine signaling favors adhesion over migration. Heterophilic interaction with PECAM1 on endothelial cells plays a role in neutrophil transendothelial migration in vitro. However, appears to be dispensable for neutrophil recruitment caused by bacterial infection in vivo. Acts as a receptor for the mature form of protease PRTN3 allowing its display at the cell surface of neutrophils. By displaying PRTN3 at the neutrophil cell surface, may play a role in enhancing endothelial cell junctional integrity and thus vascular integrity during neutrophil diapedesis.
Protein Name	Cd177 Antigen Human Neutrophil Alloantigen 2a Hna-2a Nb1 Glycoprotein Nb1 Gp Polycythemia Rubra Vera Protein 1 Prv-1 Cd Antigen Cd177
Database Links	Reactome: R-HSA-140875 Reactome: R-HSA-202733 Reactome: R-HSA-6798695
Cellular Localisation	Cell Membrane Lipid-Anchor Gpi-Anchor Membrane Raft Gpi-Like-Anchor Secreted Cytoplasmic Granule Membrane Cell Projection Lamellipodium Cell Surface Expression On Neutrophils Is Increased Upon Tnf-Alpha Fmlp Or Cxcl8/Il8-Mediated Stimulation In Neutrophils Stored Predominantly In Secondary And Tertiary Granules Can Also Be Shedded From The Cell Membrane Localizes To Lamellar Protrusions In Spreading Neutrophils
Alternative Antibody Names	Anti-Cd177 Antigen antibody Anti-Human Neutrophil Alloantigen 2a antibody Anti-Hna-2a antibody Anti-Nb1 Glycoprotein antibody Anti-Nb1 Gp antibody Anti-Polycythemia Rubra Vera Protein 1 antibody Anti-Prv-1 antibody Anti-Cd Antigen Cd177 antibody Anti-CD177 antibody Anti-NB1 antibody Anti-PRV1 antibody Anti-UNQ595 antibody Anti-PRO1181 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CD177 antibody (35-285) (STJ115558)