Human MAPRE1 (Microtubule Associated Protein RP/EB Family, Member 1) Sandwich ELISA Kit (STJE0010486) STJE0010486 上海玉博生物科技有限公司

Human MAPRE1 (Microtubule Associated Protein RP/EB Family, Member 1) Sandwich ELISA Kit (STJE0010486)

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产品名称：Human MAPRE1 (Microtubule Associated Protein RP/EB Family, Member 1) Sandwich ELISA Kit (STJE0010486)
产品型号：STJE0010486
产品展商：ST john's laboratory
产品文档：无相关文档

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Human MAPRE1 (Microtubule Associated Protein RP/EB Family, Member 1) Sandwich ELISA Kit (STJE0010486)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.036ng/mL
Detection Limit:	0.156-10ng/mL
Short Description:	This MAPRE1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	MAPRE1
Gene ID:	22919
Uniprot ID:	MARE1_HUMAN
Sample Type:	tissue homogenates, cell lysates or other biological fluids.

Tissue Specificity	Ubiquitously expressed.
Post Translational Modifications	Acetylation at Lys-220 by KAT2B/PCAF promotes dynamic kinetochore-microtubule interactions in early mitosis. Crotonylated by KAT5 during mitosis, promoting astral microtubule plasticity and dynamic connection between astral microtubules and the cortex during mitotic chromosome segregation, thereby ensuring accurate spindle positioning in mitosis. Decrotonylated by HDAC3.
Function	Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. Involved in mitotic spindle positioning by stabilizing microtubules and promoting dynamic connection between astral microtubules and the cortex during mitotic chromosome segregation. Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement. Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules. Acts as a regulator of autophagosome transport via interaction with CAMSAP2. Functions downstream of Rho GTPases and DIAPH1 in stable microtubule formation. May play a role in cell migration.
Protein Name	Microtubule-Associated Protein Rp/Eb Family Member 1 Apc-Binding Protein Eb1 End-Binding Protein 1 Eb1
Database Links	Reactome: R-HSA-141444 Reactome: R-HSA-2467813 Reactome: R-HSA-2500257 Reactome: R-HSA-2565942 Reactome: R-HSA-380259 Reactome: R-HSA-380270 Reactome: R-HSA-380284 Reactome: R-HSA-380320 Reactome: R-HSA-5620912 Reactome: R-HSA-5663220 Reactome: R-HSA-68877 Reactome: R-HSA-8852276 Reactome: R-HSA-8854518 Reactome: R-HSA-9648025
Cellular Localisation	Cytoplasm Cytoskeleton Microtubule Organizing Center Centrosome Golgi Apparatus Spindle Spindle Pole Associated With The Microtubule Growing Distal Tips Recruitment To The Golgi Apparatus Requires The Presence Of Pde4dip Isoform 13/Mmg8/Smyle
Alternative ELISA Names	Microtubule-Associated Protein Rp/Eb Family Member 1 ELISA kit Apc-Binding Protein Eb1 ELISA kit End-Binding Protein 1 ELISA kit Eb1 ELISA kit MAPRE1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human MAPRE1 (Microtubule Associated Protein RP/EB Family, Member 1) Sandwich ELISA Kit (STJE0010486)