Anti-Beta 1 Integrin antibody [BV7] (STJ16100152) STJ16100152-1 上海玉博生物科技有限公司

Anti-Beta 1 Integrin antibody [BV7] (STJ16100152)

如果您对该产品感兴趣的话，可以
产品名称：Anti-Beta 1 Integrin antibody [BV7] (STJ16100152)
产品型号：STJ16100152-1
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-Beta 1 Integrin antibody [BV7] (STJ16100152)

产品描述

Host:	Mouse
Applications:	FC/ELISA/IP/WB
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Mouse monoclonal antibody anti-Beta 1 Integrin is suitable for use in Flow Cytometry, ELISA, Immunoprecipitation and Western Blot research applications.

Clonality:	Monoclonal
Clone ID:	BV7
Conjugation:	Unconjugated
Isotype:	IgG1
Formulation:	PBS with 0.1% BSA and 0.02% sodium azide
Concentration:	100 ug/mL
Dilution Range:	FC 1:50 ELISA 1:50 WB 1:50 IP 1:50
Storage Instruction:	Store at 2-8°C upon receipt.

Background

The monoclonal antibody BV7 recognizes human ÃŸ1-integrin. Beta-1 integrin is a ubiquitously expressed ~89 kDa type I transmembrane protein functioning as receptor when heterodimerized with one alpha subunit. It belongs to the integrin beta chain family consisting of four different genes, encoding multiple Î²-integrins via alternative splicing. Ligand-recognition depends on the composition of the heterodimer: either collagen, fibronectin, VCAM1, laminin, cytotactin, osteopontin, epiligrin, thrombospondin and CSPG4 can bind to the integrin-complex. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform beta-1B interferes with isoform beta-1A resulting in a dominant negative effect on cell adhesion and migration (in vitro). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi s sarcoma lesions. When associated with Alpha 7, Î²1-integrin regulates cell adhesion and laminin matrix deposition. BV7 is active on HT-29 colon carcinoma cells and on HCCP-2998 tumor cells. It is involved in promoting endothelial cell motility and angiogenesis. Furthermore, Î²1-integrin plays a mechanistic adhesive role during telophase, and is required for the successful completion of cytokinesis. Upon activation integrins in general, including Î²1-integrin, are known to exhibit global structural rearrangements and exposure of ligand binding sites. Î²1-integrin modulation is of importance in tissue repair and regeneration. In cultured primary hippocampal neurons, astrocytes and tissues, cell surface expression of amyloid beta fibrils (key hallmark of Alzheimerâ€™s disease) selectively co-localized with Î²1-integrin. Preincubation of cells with antibodies against Î²1-integrin, as well as Alpha 1-integrin, greatly enhanced amyloid beta-induced apoptosis, indicating a protective role for integrins in apoptosis. The monoclonal antibody BV7 does not recognize Alpha 5Î²1 complex and not the cytoplasmic part of the Î²1-subunit. Monoclonal antibody BV7 is active on HT-29 colon carcinoma cells and on HCCP-2998 tumor cells. BV7 binds to several other tumor cells (MG3 osteosarcoma, A375 melanoma, MHCC-1410 and Lovo colon carcinoma) but does not affect adhesion to endothelial cells.

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

产品留言

标题

联系人

联系电话

内容

验证码

点击换一张

注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
2.如有必要,请您留下您的详细联系方式!

温馨提示：为规避购买风险，建议您在购买前务必确认供应商资质与产品质量。
免责申明：以上内容为注册会员自行发布，若信息的真实性、合法性存在争议，平台将会监督协助处理，欢迎举报

产品目录

产品资料

Anti-Beta 1 Integrin antibody [BV7] (STJ16100152)