Human MERTK (C-Mer Proto Oncogene Tyrosine Kinase) Sandwich ELISA Kit (STJE0010561) STJE0010561 上海玉博生物科技有限公司

Human MERTK (C-Mer Proto Oncogene Tyrosine Kinase) Sandwich ELISA Kit (STJE0010561)

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产品名称：Human MERTK (C-Mer Proto Oncogene Tyrosine Kinase) Sandwich ELISA Kit (STJE0010561)
产品型号：STJE0010561
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human MERTK (C-Mer Proto Oncogene Tyrosine Kinase) Sandwich ELISA Kit (STJE0010561)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.113ng/mL
Detection Limit:	0.312-20ng/mL
Short Description:	This MERTK Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	MERTK
Gene ID:	10461
Uniprot ID:	MERTK_HUMAN
Sample Type:	tissue homogenates, cell lysates or other biological fluids.

Tissue Specificity	Not expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines. Highly expressed in testis, ovary, prostate, lung, and kidney, with lower expression in spleen, small intestine, colon, and liver.
Post Translational Modifications	Autophosphorylated on Tyr-749, Tyr-753 and Tyr-754 in the activation loop allowing full activity. Autophosphorylated on Tyr-872 leading to recruitment of downstream partners of the signaling cascade such as PLCG2.
Function	Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
Protein Name	Tyrosine-Protein Kinase Mer Proto-Oncogene C-Mer Receptor Tyrosine Kinase Mertk
Database Links	Reactome: R-HSA-202733
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein
Alternative ELISA Names	Tyrosine-Protein Kinase Mer ELISA kit Proto-Oncogene C-Mer ELISA kit Receptor Tyrosine Kinase Mertk ELISA kit MERTK ELISA kit MER ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human MERTK (C-Mer Proto Oncogene Tyrosine Kinase) Sandwich ELISA Kit (STJE0010561)