Anti-CD207 antibody (70-327) (STJ28636) STJ28636 上海玉博生物科技有限公司

Anti-CD207 antibody (70-327) (STJ28636)

简单介绍

Anti-CD207 antibody (70-327) (STJ28636)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-CD207 (70-327) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CD207
Gene ID:	50489
Uniprot ID:	CLC4K_HUMAN
Immunogen Region:	70-327
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 70-327 of human Langerin/CD207 (NP_056532.4).
Immunogen Sequence:	TISDVKTNVQLLKGRVDNIS TLDSEIKKNSDGMEAAGVQI QMVNESLGYVRSQFLKLKTS VEKANAQIQILTRSWEEVST LNAQIPELKSDLEKASALNT KIRALQGSLENMSKLLKRQN DILQVVSQGWK

Tissue Specificity	Exclusively expressed by Langerhans cells. Expressed in astrocytoma and malignant ependymoma, but not in normal brain tissues.
Function	Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs).is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.
Protein Name	C-Type Lectin Domain Family 4 Member K Langerin Cd Antigen Cd207
Database Links	Reactome: R-HSA-1236978
Cellular Localisation	Membrane Single-Pass Type Ii Membrane Protein Found In Birbeck Granules (Bgs) Which Are Organelles Consisting Of Superimposed And Zippered Membranes
Alternative Antibody Names	Anti-C-Type Lectin Domain Family 4 Member K antibody Anti-Langerin antibody Anti-Cd Antigen Cd207 antibody Anti-CD207 antibody Anti-CLEC4K antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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