Anti-CD209 antibody (265-404) (STJ111093) STJ111093 上海玉博生物科技有限公司

Anti-CD209 antibody (265-404) (STJ111093)

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产品名称：Anti-CD209 antibody (265-404) (STJ111093)
产品型号：STJ111093
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CD209 antibody (265-404) (STJ111093)

产品描述

Host:	Rabbit
Applications:	WB/IF
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-CD209 (265-404) is suitable for use in Western Blot and Immunofluorescence research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000 IF/ICC 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CD209
Gene ID:	30835
Uniprot ID:	CD209_HUMAN
Immunogen Region:	265-404
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 265-404 of human CD209 (NP_066978.1).
Immunogen Sequence:	GNCYFMSNSQRNWHDSITAC KEVGAQLVVIKSAEEQNFLQ LQSSRSNRFTWMGLSDLNQE GTWQWVDGSPLLPSFKQYWN RGEPNNVGEEDCAEFSGNGW NDDKCNLAKFWICKKSAASC SRDEEQFLSPAPATPNPPPA

Tissue Specificity	Predominantly expressed in dendritic cells and in DC-residing tissues. Also found in placental macrophages, endothelial cells of placental vascular channels, peripheral blood mononuclear cells, and THP-1 monocytes.
Function	Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2. Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in the immunological synapse formed between DC and T-cells. (Microbial infection) Acts as an attachment receptor for HIV-1 and HIV-2. (Microbial infection) Acts as an attachment receptor for Ebolavirus. (Microbial infection) Acts as an attachment receptor for Cytomegalovirus. (Microbial infection) Acts as an attachment receptor for HCV. (Microbial infection) Acts as an attachment receptor for Dengue virus. (Microbial infection) Acts as an attachment receptor for Measles virus. (Microbial infection) Acts as an attachment receptor for Herpes simplex virus 1. (Microbial infection) Acts as an attachment receptor for Influenzavirus A. (Microbial infection) Acts as an attachment receptor for SARS-CoV. (Microbial infection) Acts as an attachment receptor for Japanese encephalitis virus. (Microbial infection) Acts as an attachment receptor for Lassa virus. Acts as an attachment receptor for Marburg virusn. (Microbial infection) Acts as an attachment receptor for Respiratory syncytial virus. (Microbial infection) Acts as an attachment receptor for Rift valley fever virus and uukuniemi virus. (Microbial infection) Acts as an attachment receptor for West-nile virus. (Microbial infection) Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of bacterial pathogen antigens, including Leishmania pifanoi LPG, Lewis-x antigen in Helicobacter pylori LPS, mannose in Klebsiella pneumonae LPS, di-mannose and tri-mannose in Mycobacterium tuberculosis ManLAM and Lewis-x antigen in Schistosoma mansoni SEA. Recognition of M.tuberculosis by dendritic cells occurs partially via this molecule.
Protein Name	Cd209 Antigen C-Type Lectin Domain Family 4 Member L Dendritic Cell-Specific Icam-3-Grabbing Non-Integrin 1 Dc-Sign Dc-Sign1 Cd Antigen Cd209
Database Links	Reactome: R-HSA-5621575 Reactome: R-HSA-8851680
Cellular Localisation	Isoform 1: Cell Membrane Single-Pass Type Ii Membrane Protein Isoform 2: Cell Membrane Isoform 3: Cell Membrane Isoform 4: Cell Membrane Isoform 5: Cell Membrane Isoform 6: Secreted Isoform 7: Secreted Isoform 8: Secreted Isoform 9: Secreted Isoform 10: Secreted Isoform 11: Secreted Isoform 12: Secreted
Alternative Antibody Names	Anti-Cd209 Antigen antibody Anti-C-Type Lectin Domain Family 4 Member L antibody Anti-Dendritic Cell-Specific Icam-3-Grabbing Non-Integrin 1 antibody Anti-Dc-Sign antibody Anti-Dc-Sign1 antibody Anti-Cd Antigen Cd209 antibody Anti-CD209 antibody Anti-CLEC4L antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CD209 antibody (265-404) (STJ111093)