Anti-CD22 antibody (776-825 aa) (STJ92105) STJ92105 上海玉博生物科技有限公司

Anti-CD22 antibody (776-825 aa) (STJ92105)

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产品名称：Anti-CD22 antibody (776-825 aa) (STJ92105)
产品型号：STJ92105
产品展商：ST john's laboratory
产品文档：无相关文档

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Anti-CD22 antibody (776-825 aa) (STJ92105)

产品描述

Host:	Rabbit
Applications:	WB/ELISA
Reactivity:	Human/Rat/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-B-cell receptor CD22 (776-825 aa) is suitable for use in Western Blot and ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-1:2000 ELISA 1:40000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CD22
Gene ID:	933
Uniprot ID:	CD22_HUMAN
Immunogen Region:	776-825 aa
Specificity:	CD22 Polyclonal Antibody detects endogenous levels of CD22 protein.
Immunogen:	The antiserum was produced against synthesized peptide derived from the human BL-CAM at the amino acid range 776-825

Post Translational Modifications	Phosphorylation of Tyr-762, Tyr-807 and Tyr-822 are involved in binding to SYK, GRB2 and SYK, respectively. Phosphorylation of Tyr-842 is involved in binding to SYK, PLCG2 and PIK3R1/PIK3R2. Phosphorylated on tyrosine residues by LYN.
Function	Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins.one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
Protein Name	B-Cell Receptor Cd22 B-Lymphocyte Cell Adhesion Molecule Bl-Cam Sialic Acid-Binding Ig-Like Lectin 2 Siglec-2 T-Cell Surface Antigen Leu-14 Cd Antigen Cd22
Database Links	Reactome: R-HSA-198933 Reactome: R-HSA-5690714 Reactome: R-HSA-983695
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein
Alternative Antibody Names	Anti-B-Cell Receptor Cd22 antibody Anti-B-Lymphocyte Cell Adhesion Molecule antibody Anti-Bl-Cam antibody Anti-Sialic Acid-Binding Ig-Like Lectin 2 antibody Anti-Siglec-2 antibody Anti-T-Cell Surface Antigen Leu-14 antibody Anti-Cd Antigen Cd22 antibody Anti-CD22 antibody Anti-SIGLEC2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CD22 antibody (776-825 aa) (STJ92105)