Anti-BEX2 antibody (28-78 aa) (STJ195275) STJ195275 上海玉博生物科技有限公司

Anti-BEX2 antibody (28-78 aa) (STJ195275)

简单介绍

Anti-BEX2 antibody (28-78 aa) (STJ195275)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Protein BEX2 (28-78 aa) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	BEX2
Gene ID:	84707
Uniprot ID:	BEX2_HUMAN
Immunogen Region:	28-78 aa
Specificity:	This antibody detects endogenous levels of BEX2 at Human/Mouse/Rat
Immunogen:	Synthesized peptide derived from the human BEX2 at the amino acid range 28-78

Function	Regulator of mitochondrial apoptosis and G1 cell cycle in breast cancer. Protects the breast cancer cells against mitochondrial apoptosis and this effect is mediated through the modulation of BCL2 protein family, which involves the positive regulation of anti-apoptotic member BCL2 and the negative regulation of pro-apoptotic members BAD, BAK1 and PUMA. Required for the normal cell cycle progression during G1 in breast cancer cells through the regulation of CCND1 and CDKN1A. Regulates the level of PP2A regulatory subunit B and PP2A phosphatase activity. In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates.
Protein Name	Protein Bex2 Brain-Expressed X-Linked Protein 2 Hbex2
Cellular Localisation	Cytoplasm Nucleus
Alternative Antibody Names	Anti-Protein Bex2 antibody Anti-Brain-Expressed X-Linked Protein 2 antibody Anti-Hbex2 antibody Anti-BEX2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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