Anti-BHLHE22 antibody (Internal) (STJ73538) STJ73538-100 上海玉博生物科技有限公司

Anti-BHLHE22 antibody (Internal) (STJ73538)

简单介绍

Anti-BHLHE22 antibody (Internal) (STJ73538)

产品描述

Host:	Goat
Applications:	Pep-ELISA/WB
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Goat polyclonal antibody anti-BHLHE22 (Internal) is suitable for use in ELISA and Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	0.5 mg/mL
Dilution Range:	WB-Recommended concentration:0.1-0.3µg/ml ELISA-antibody detection limit dilution 1:128000.
Storage Instruction:	Store at-20°C on receipt and minimise freeze-thaw cycles.

Function	Inhibits DNA binding of TCF3/E47 homodimers and TCF3 (E47)/NEUROD1 heterodimers and acts as a strong repressor of Neurod1 and Myod-responsive genes, probably by heterodimerization with class a basic helix-loop-helix factors. Despite the presence of an intact basic domain, does not bind to DNA. In the brain, may function as an area-specific transcription factor that regulates the postmitotic acquisition of area identities and elucidate the genetic hierarchy between progenitors and postmitotic neurons driving neocortical arealization. May be required for the survival of a specific population of inhibitory neurons in the superficial laminae of the spinal cord dorsal horn that may regulate pruritis. Seems to play a crucial role in the retinogenesis, in the specification of amacrine and bipolar subtypes. Forms with PRDM8 a transcriptional repressor complex controlling genes involved in neural development and neuronal differentiation.
Protein Name	Class E Basic Helix-Loop-Helix Protein 22 Bhlhe22 Class B Basic Helix-Loop-Helix Protein 5 Bhlhb5 Trinucleotide Repeat-Containing Gene 20 Protein
Database Links	Reactome: R-HSA-9762293
Cellular Localisation	Nucleus
Alternative Antibody Names	Anti-Class E Basic Helix-Loop-Helix Protein 22 antibody Anti-Bhlhe22 antibody Anti-Class B Basic Helix-Loop-Helix Protein 5 antibody Anti-Bhlhb5 antibody Anti-Trinucleotide Repeat-Containing Gene 20 Protein antibody Anti-BHLHE22 antibody Anti-BHLHB5 antibody Anti-TNRC20 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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