Human MLH1 (MutL Homolog 1) Sandwich ELISA Kit (STJE0010628) STJE0010628 上海玉博生物科技有限公司

Human MLH1 (MutL Homolog 1) Sandwich ELISA Kit (STJE0010628)

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产品名称：Human MLH1 (MutL Homolog 1) Sandwich ELISA Kit (STJE0010628)
产品型号：STJE0010628
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human MLH1 (MutL Homolog 1) Sandwich ELISA Kit (STJE0010628)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.057ng/mL
Detection Limit:	0.156-10ng/mL
Short Description:	This MLH1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	MLH1
Gene ID:	4292
Uniprot ID:	MLH1_HUMAN
Sample Type:	tissue homogenates, cell lysates or other biological fluids.

Tissue Specificity	Colon, lymphocytes, breast, lung, spleen, testis, prostate, thyroid, gall bladder and heart.
Post Translational Modifications
Function	Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma which plays a role in meiosis.
Protein Name	Dna Mismatch Repair Protein Mlh1 Mutl Protein Homolog 1
Database Links	Reactome: R-HSA-5358565 Reactome: R-HSA-5358606 Reactome: R-HSA-5545483 Reactome: R-HSA-5632987 Reactome: R-HSA-6796648 Reactome: R-HSA-912446
Cellular Localisation	Nucleus Chromosome Recruited To Chromatin In A Mcm9-Dependent Manner
Alternative ELISA Names	Dna Mismatch Repair Protein Mlh1 ELISA kit Mutl Protein Homolog 1 ELISA kit MLH1 ELISA kit COCA2 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human MLH1 (MutL Homolog 1) Sandwich ELISA Kit (STJE0010628)