Human MLKL (Mixed Lineage Kinase Domain Like Protein) Sandwich ELISA Kit (STJE0010629) STJE0010629 上海玉博生物科技有限公司

Human MLKL (Mixed Lineage Kinase Domain Like Protein) Sandwich ELISA Kit (STJE0010629)

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产品名称：Human MLKL (Mixed Lineage Kinase Domain Like Protein) Sandwich ELISA Kit (STJE0010629)
产品型号：STJE0010629
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human MLKL (Mixed Lineage Kinase Domain Like Protein) Sandwich ELISA Kit (STJE0010629)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	11.6pg/mL
Detection Limit:	31.2-2000pg/mL
Short Description:	This MLKL Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	MLKL
Gene ID:	197259
Uniprot ID:	MLKL_HUMAN
Sample Type:	tissue homogenates, cell lysates or other biological fluids.

Tissue Specificity
Post Translational Modifications	Phosphorylation by RIPK3 induces a conformational switch that is required for necroptosis. It also induces homotrimerization and localization to the plasma membrane.
Function	Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Does not have protein kinase activity. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: following activation by ZBP1, MLKL is phosphorylated by RIPK3 in the nucleus, triggering disruption of the nuclear envelope and leakage of cellular DNA into the cytosol.following ZBP1 activation, which senses double-stranded Z-RNA structures, nuclear RIPK3 catalyzes phosphorylation and activation of MLKL, promoting disruption of the nuclear envelope and leakage of cellular DNA into the cytosol. Binds to highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which is essential for its necroptotic function.
Protein Name	Mixed Lineage Kinase Domain-Like Protein Hmlkl
Database Links	Reactome: R-HSA-3295583 Reactome: R-HSA-5213460 Reactome: R-HSA-5675482 Reactome: R-HSA-9686347
Cellular Localisation	Cytoplasm Cell Membrane Nucleus Localizes To The Cytoplasm And Translocates To The Plasma Membrane On Necroptosis Induction Localizes To The Nucleus In Response To Orthomyxoviruses Infection
Alternative ELISA Names	Mixed Lineage Kinase Domain-Like Protein ELISA kit Hmlkl ELISA kit MLKL ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human MLKL (Mixed Lineage Kinase Domain Like Protein) Sandwich ELISA Kit (STJE0010629)