Anti-CD244 antibody (101-150 aa) (STJ97310) STJ97310 上海玉博生物科技有限公司

Anti-CD244 antibody (101-150 aa) (STJ97310)

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产品名称：Anti-CD244 antibody (101-150 aa) (STJ97310)
产品型号：STJ97310
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CD244 antibody (101-150 aa) (STJ97310)

产品描述

Host:	Rabbit
Applications:	WB/IHC/IF/ELISA
Reactivity:	Human/Rat/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Natural killer cell receptor 2B4 (101-150 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-1:2000 IHC-P 1:100-1:300 ELISA 1:10000 IF 1:50-200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CD244
Gene ID:	51744
Uniprot ID:	CD244_HUMAN
Immunogen Region:	101-150 aa
Specificity:	CD244 Polyclonal Antibody detects endogenous levels of CD244 protein.
Immunogen:	The antiserum was produced against synthesized peptide derived from the Internal region of human CD244 at the amino acid range 101-150

Post Translational Modifications	N-linked glycosylation is essential for the binding to its ligand CD48. Also O-glycosylated, in contrast, O-linked sialylation has a negative impact on ligand binding. Phosphorylated by FYN and CSK on tyrosine residues following activation. Coligation with inhibitory receptors such as KIR2DL1 inhibits phosphorylation upon contact of NK cells with sensitive target cells.
Function	Heterophilic receptor of the signaling lymphocytic activation molecule (SLAM) family.its ligand is CD48. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Acts as activating natural killer (NK) cell receptor. Activating function implicates association with SH2D1A and FYN. Downstreaming signaling involves predominantly VAV1, and, to a lesser degree, INPP5D/SHIP1 and CBL. Signal attenuation in the absence of SH2D1A is proposed to be dependent on INPP5D and to a lesser extent PTPN6/SHP-1 and PTPN11/SHP-2. Stimulates NK cell cytotoxicity, production of IFN-gamma and granule exocytosis. Optimal expansion and activation of NK cells seems to be dependent on the engagement of CD244 with CD48 expressed on neighboring NK cells. Acts as costimulator in NK activation by enhancing signals by other NK receptors such as NCR3 and NCR1. At early stages of NK cell differentiation may function as an inhibitory receptor possibly ensuring the self-tolerance of developing NK cells. Involved in the regulation of CD8(+) T-cell proliferation.expression on activated T-cells and binding to CD48 provides costimulatory-like function for neighboring T-cells. Inhibits inflammatory responses in dendritic cells (DCs).
Protein Name	Natural Killer Cell Receptor 2b4 Nk Cell Activation-Inducing Ligand Nail Nk Cell Type I Receptor Protein 2b4 Nkr2b4 H2b4 Slam Family Member 4 Slamf4 Signaling Lymphocytic Activation Molecule 4 Cd Antigen Cd244
Database Links	Reactome: R-HSA-202733
Cellular Localisation	Membrane Single-Pass Type I Membrane Protein Cell Membrane Receptor Engagement Results In A Recruitment To Lipid Drafts Essential For The Subsequent Tyrosine Phosphorylation Of The Itsms
Alternative Antibody Names	Anti-Natural Killer Cell Receptor 2b4 antibody Anti-Nk Cell Activation-Inducing Ligand antibody Anti-Nail antibody Anti-Nk Cell Type I Receptor Protein 2b4 antibody Anti-Nkr2b4 antibody Anti-H2b4 antibody Anti-Slam Family Member 4 antibody Anti-Slamf4 antibody Anti-Signaling Lymphocytic Activation Molecule 4 antibody Anti-Cd Antigen Cd244 antibody Anti-CD244 antibody Anti-2B4 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CD244 antibody (101-150 aa) (STJ97310)