Anti-BID antibody (C-Term) (STJ70684) STJ70684-100 上海玉博生物科技有限公司

Anti-BID antibody (C-Term) (STJ70684)

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产品名称：Anti-BID antibody (C-Term) (STJ70684)
产品型号：STJ70684-100
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-BID antibody (C-Term) (STJ70684)

产品描述

Host:	Goat
Applications:	Pep-ELISA/WB/IF
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Goat polyclonal antibody anti-BID (C-Term) is suitable for use in ELISA, Western Blot and Immunofluorescence research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	0.5 mg/mL
Dilution Range:	WB-0.1-0.3µg/ml IF-Immunofluorescence: Strong expression of the protein seen in the cytoplasm of MCF7 cells. 10µg/ml ELISA-antibody detection limit dilution 1:8000.
Storage Instruction:	Store at-20°C on receipt and minimise freeze-thaw cycles.

Gene Symbol:	BID
Gene ID:	637
Uniprot ID:	BID_HUMAN
Immunogen Region:	C-Term
Accession Number:	NP_932070.1; NP_001187.1; NP_932071.1
Specificity:	This antibody is expected to recognise all three reported isoforms (as represented by NP_932070.1; NP_001187.1; NP_932071.1)
Immunogen Sequence:	TYVRSLARNGMD

Post Translational Modifications	BH3-interacting domain death agonist: TNF-alpha induces caspase-mediated cleavage into a major p15 and minor p13 and p11 products. Cleaved by CASP6 into a major p15 and minor p13 products, leading to release of cytochrome c and subsequent nonalcoholic steatohepatitis. BH3-interacting domain death agonist p15: Ubiquitinated by ITCH.ubiquitination results in proteasome-dependent degradation.
Function	Induces caspases and apoptosis. Counters the protective effect of BCL2. BH3-interacting domain death agonist p15: Induces caspase activation and apoptosis. Allows the release of cytochrome c. Isoform 1: Induces ICE-like proteases and apoptosis. Isoform 2: Induces ICE-like proteases and apoptosis. Isoform 3: Does not induce apoptosis. Isoform 4: Induces ICE-like proteases and apoptosis.
Protein Name	Bh3-Interacting Domain Death Agonist P22 Bid Bid Cleaved Into - Bh3-Interacting Domain Death Agonist P15 P15 Bid - Bh3-Interacting Domain Death Agonist P13 P13 Bid - Bh3-Interacting Domain Death Agonist P11 P11 Bid
Database Links	Reactome: R-HSA-111447 Reactome: R-HSA-111452 Reactome: R-HSA-111453 Reactome: R-HSA-114294 Reactome: R-HSA-6803204 Reactome: R-HSA-75108
Cellular Localisation	Cytoplasm Mitochondrion Membrane Mitochondrion Outer Membrane When Uncleaved It Is Predominantly Cytoplasmic Bh3-Interacting Domain Death Agonist P15: Mitochondrion Membrane Translocates To Mitochondria As An Integral Membrane Protein Bh3-Interacting Domain Death Agonist P13: Mitochondrion Membrane Associated With The Mitochondrial Membrane Isoform 1: Cytoplasm Isoform 3: Cytoplasm Isoform 2: Mitochondrion Membrane A Significant Proportion Of Isoform 2 Localizes To Mitochondria It May Be Cleaved Constitutively
Alternative Antibody Names	Anti-Bh3-Interacting Domain Death Agonist antibody Anti-P22 Bid antibody Anti-Bid Cleaved Into - Bh3-Interacting Domain Death Agonist P15 antibody Anti-P15 Bid - Bh3-Interacting Domain Death Agonist P13 antibody Anti-P13 Bid - Bh3-Interacting Domain Death Agonist P11 antibody Anti-P11 Bid antibody Anti-BID antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-BID antibody (C-Term) (STJ70684)