Anti-BIF-1/SH3GLB1 antibody (C-Term) (STJ70058) STJ70058-100 上海玉博生物科技有限公司

Anti-BIF-1/SH3GLB1 antibody (C-Term) (STJ70058)

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产品名称：Anti-BIF-1/SH3GLB1 antibody (C-Term) (STJ70058)
产品型号：STJ70058-100
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-BIF-1/SH3GLB1 antibody (C-Term) (STJ70058)

产品描述

Host:	Goat
Applications:	Pep-ELISA/WB/IHC/FC
Reactivity:	Human/Mouse/Rat/Dog/Cow
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Goat polyclonal antibody anti-BIF-1/SH3GLB1 (C-Term) is suitable for use in ELISA, Western Blot, Immunohistochemistry and Flow Cytometry research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	0.5 mg/mL
Dilution Range:	IHC-2.5µg/ml FC-Flow cytometric analysis of A431 cells. 10ug/ml ELISA-antibody detection limit dilution 1:32000.
Storage Instruction:	Store at-20°C on receipt and minimise freeze-thaw cycles.

Gene Symbol:	SH3GLB1
Gene ID:	51100
Uniprot ID:	SHLB1_HUMAN
Immunogen Region:	C-Term
Accession Number:	NP_057093.1; NP_001193580.1; NP_001193581.1; NP_001193582.1
Immunogen Sequence:	QKGKVPITYLELLN

Post Translational Modifications	Phosphorylated at Thr-145 by CDK5.this phosphorylation is required for autophagy induction in starved neurons and facilitates homodimerization.
Function	May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells. May recruit other proteins to membranes with high curvature. May promote membrane fusion. Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation. Isoform 1 acts proapoptotic in fibroblasts. Involved in caspase-independent apoptosis during nutrition starvation and involved in the regulation of autophagy. Activates lipid kinase activity of PIK3C3 during autophagy probably by associating with the PI3K complex II (PI3KC3-C2). Associated with PI3KC3-C2 during autophagy may regulate the trafficking of ATG9A from the Golgi complex to the peripheral cytoplasm for the formation of autophagosomes by inducing Golgi membrane tubulation and fragmentation. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2. Isoform 2 acts antiapoptotic in neuronal cells.involved in maintenance of mitochondrial morphology and promotes neuronal viability.
Protein Name	Endophilin-B1 Bax-Interacting Factor 1 Bif-1 Sh3 Domain-Containing Grb2-Like Protein B1
Cellular Localisation	Cytoplasm Golgi Apparatus Membrane Peripheral Membrane Protein Mitochondrion Outer Membrane Cytoplasmic Vesicle Autophagosome Membrane Midbody Association With The Golgi Apparatus Depends On The Cell Type Following Starvation Colocalizes With Atg5 And Lc3 Autophagy-Related Protein(S)On Autophagosomal Membranes
Alternative Antibody Names	Anti-Endophilin-B1 antibody Anti-Bax-Interacting Factor 1 antibody Anti-Bif-1 antibody Anti-Sh3 Domain-Containing Grb2-Like Protein B1 antibody Anti-SH3GLB1 antibody Anti-KIAA0491 antibody Anti-CGI-61 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-BIF-1/SH3GLB1 antibody (C-Term) (STJ70058)