Anti-BIM antibody (C-Term) (STJ70563) STJ70563-100 上海玉博生物科技有限公司

Anti-BIM antibody (C-Term) (STJ70563)

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产品名称：Anti-BIM antibody (C-Term) (STJ70563)
产品型号：STJ70563-100
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-BIM antibody (C-Term) (STJ70563)

产品描述

Host:	Goat
Applications:	Pep-ELISA/WB
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Goat polyclonal antibody anti-BIM (C-Term) is suitable for use in ELISA and Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	0.5 mg/mL
Dilution Range:	WB-Recommended for use at 0.5-2µg/ml ELISA-antibody detection limit dilution 1:16000.
Storage Instruction:	Store at-20°C on receipt and minimise freeze-thaw cycles.

Gene Symbol:	BCL2L11
Gene ID:	10018
Uniprot ID:	B2L11_HUMAN
Immunogen Region:	C-Term
Accession Number:	NP_619528.1; NP_619529.1; NP_996886.1;
Specificity:	This antibody is expected to recognise at least reported isoforms Bim-alpha1 (BimABCD) , Bim-alpha2 (BimACD) and Bim-alpha3 (BimAD).
Immunogen Sequence:	FNAYYARRLEK

Post Translational Modifications	Phosphorylation at Ser-69 by MAPK1/MAPK3 leads to interaction with TRIM2 and polyubiquitination, followed by proteasomal degradation. Deubiquitination catalyzed by USP27X stabilizes the protein. Ubiquitination by TRIM2 following phosphorylation by MAPK1/MAPK3 leads to proteasomal degradation. Conversely, deubiquitination catalyzed by USP27X stabilizes the protein.
Function	Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis.
Protein Name	Bcl-2-Like Protein 11 Bcl2-L-11 Bcl2-Interacting Mediator Of Cell Death
Database Links	Reactome: R-HSA-111446 Reactome: R-HSA-111453 Reactome: R-HSA-193648 Reactome: R-HSA-6802952 Reactome: R-HSA-8862803 Reactome: R-HSA-8952158 Reactome: R-HSA-9607240 Reactome: R-HSA-9614657
Cellular Localisation	Endomembrane System Peripheral Membrane Protein Associated With Intracytoplasmic Membranes Isoform Bimel: Mitochondrion Translocates From Microtubules To Mitochondria On Loss Of Cell Adherence Isoform Biml: Mitochondrion Isoform Bims: Mitochondrion Isoform Bim-Alpha1: Mitochondrion
Alternative Antibody Names	Anti-Bcl-2-Like Protein 11 antibody Anti-Bcl2-L-11 antibody Anti-Bcl2-Interacting Mediator Of Cell Death antibody Anti-BCL2L11 antibody Anti-BIM antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-BIM antibody (C-Term) (STJ70563)