Anti-BIN1 antibody (Internal) (STJ71638) STJ71638-100 上海玉博生物科技有限公司

Anti-BIN1 antibody (Internal) (STJ71638)

简单介绍

Anti-BIN1 antibody (Internal) (STJ71638)

产品描述

Host:	Goat
Applications:	Pep-ELISA/WB
Reactivity:	Human/Mouse/Rat/Dog/Pig/Cow
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Goat polyclonal antibody anti-BIN1 (Internal) is suitable for use in ELISA and Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	0.5 mg/mL
Dilution Range:	ELISA-antibody detection limit dilution 1:1000.
Storage Instruction:	Store at-20°C on receipt and minimise freeze-thaw cycles.

Gene Symbol:	BIN1
Gene ID:	274
Uniprot ID:	BIN1_HUMAN
Immunogen Region:	Internal
Accession Number:	NP_004296.1; NP_647593.1; NP_647594.1; NP_647595.1; NP_647596.1; NP_647597.1; NP_647598.1; NP_647599.1; NP_647600.1; NP_647601.1
Specificity:	This antibody is expected to recognise all ten reported isoforms (NP_647593.1, NP_647594.1, NP_647595.1, NP_647596.1, NP_647597.1, NP_647598.1, NP_647599.1, NP_004296.1, NP_647600.1, NP_647601.1).
Immunogen Sequence:	SDNAPAKGNKSPS

Post Translational Modifications	Phosphorylated by protein kinase C.
Function	Is a key player in the control of plasma membrane curvature, membrane shaping and membrane remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling. Is a negative regulator of endocytosis. Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production. In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates. May be involved in the regulation of MYC activity and the control cell proliferation. Has actin bundling activity and stabilizes actin filaments against depolymerization in vitro.
Protein Name	Myc Box-Dependent-Interacting Protein 1 Amphiphysin Ii Amphiphysin-Like Protein Box-Dependent Myc-Interacting Protein 1 Bridging Integrator 1
Database Links	Reactome: R-HSA-8856828
Cellular Localisation	Isoform Bin1: Nucleus Cytoplasm Endosome Cell Membrane Sarcolemma T-Tubule Isoform Iia: Cytoplasm
Alternative Antibody Names	Anti-Myc Box-Dependent-Interacting Protein 1 antibody Anti-Amphiphysin Ii antibody Anti-Amphiphysin-Like Protein antibody Anti-Box-Dependent Myc-Interacting Protein 1 antibody Anti-Bridging Integrator 1 antibody Anti-BIN1 antibody Anti-AMPHL antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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