Anti-BIRC3 antibody (Internal) (STJ72372) STJ72372-100 上海玉博生物科技有限公司

Anti-BIRC3 antibody (Internal) (STJ72372)

如果您对该产品感兴趣的话，可以
产品名称：Anti-BIRC3 antibody (Internal) (STJ72372)
产品型号：STJ72372-100
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-BIRC3 antibody (Internal) (STJ72372)

产品描述

Host:	Goat
Applications:	Pep-ELISA/WB
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Goat polyclonal antibody anti-BIRC3 (Internal) is suitable for use in ELISA and Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	0.5 mg/mL
Dilution Range:	ELISA-antibody detection limit dilution 1:16000.
Storage Instruction:	Store at-20°C on receipt and minimise freeze-thaw cycles.

Gene Symbol:	BIRC3
Gene ID:	330
Uniprot ID:	BIRC3_HUMAN
Immunogen Region:	Internal
Accession Number:	NP_001156.1
Specificity:	Reported variants represent identical protein: NP_892007.1, NP_001156.1.
Immunogen Sequence:	SVNNLEATSQP

Post Translational Modifications	Auto-ubiquitinated and degraded by the proteasome in apoptotic cells.
Function	Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8.
Protein Name	Baculoviral Iap Repeat-Containing Protein 3 Apoptosis Inhibitor 2 Api2 Cellular Inhibitor Of Apoptosis 2 C-Iap2 Iap Homolog C Inhibitor Of Apoptosis Protein 1 Hiap-1 Hiap1 Ring Finger Protein 49 Ring-Type E3 Ubiquitin Transferase Birc3 Tnfr2-Traf-Signaling Complex Protein 1
Database Links	Reactome: R-HSA-168638 Reactome: R-HSA-168927 Reactome: R-HSA-5213460 Reactome: R-HSA-5357786 Reactome: R-HSA-5357905 Reactome: R-HSA-5357956 Reactome: R-HSA-5668541 Reactome: R-HSA-5675482 Reactome: R-HSA-5676594 Reactome: R-HSA-5689880 Reactome: R-HSA-937041
Cellular Localisation	Cytoplasm Nucleus
Alternative Antibody Names	Anti-Baculoviral Iap Repeat-Containing Protein 3 antibody Anti-Apoptosis Inhibitor 2 antibody Anti-Api2 antibody Anti-Cellular Inhibitor Of Apoptosis 2 antibody Anti-C-Iap2 antibody Anti-Iap Homolog C antibody Anti-Inhibitor Of Apoptosis Protein 1 antibody Anti-Hiap-1 antibody Anti-Hiap1 antibody Anti-Ring Finger Protein 49 antibody Anti-Ring-Type E3 Ubiquitin Transferase Birc3 antibody Anti-Tnfr2-Traf-Signaling Complex Protein 1 antibody Anti-BIRC3 antibody Anti-API2 antibody Anti-MIHC antibody Anti-RNF49 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

产品留言

标题

联系人

联系电话

内容

验证码

点击换一张

注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
2.如有必要,请您留下您的详细联系方式!

温馨提示：为规避购买风险，建议您在购买前务必确认供应商资质与产品质量。
免责申明：以上内容为注册会员自行发布，若信息的真实性、合法性存在争议，平台将会监督协助处理，欢迎举报

产品目录

产品资料

Anti-BIRC3 antibody (Internal) (STJ72372)