Human MSN (Moesin) Sandwich ELISA Kit (STJE0010738) STJE0010738 上海玉博生物科技有限公司

Human MSN (Moesin) Sandwich ELISA Kit (STJE0010738)

如果您对该产品感兴趣的话，可以
产品名称：Human MSN (Moesin) Sandwich ELISA Kit (STJE0010738)
产品型号：STJE0010738
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human MSN (Moesin) Sandwich ELISA Kit (STJE0010738)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.064ng/mL
Detection Limit:	0.156-10ng/mL
Short Description:	This MSN Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	MSN
Gene ID:	4478
Uniprot ID:	MOES_HUMAN
Sample Type:	tissue homogenates, cell lysates or other biological fluids.

Tissue Specificity	In all tissues and cultured cells studied.
Post Translational Modifications	Phosphorylation on Thr-558 is crucial for the formation of microvilli-like structures. Phosphorylation by ROCK2 suppresses the head-to-tail association of the N-terminal and C-terminal halves resulting in an opened conformation which is capable of actin and membrane-binding. Phosphorylation on Thr-558 by STK10 negatively regulates lymphocyte migration and polarization. S-nitrosylation of Cys-117 is induced by interferon-gamma and oxidatively-modified low-densitity lipoprotein (LDL(ox)) implicating the iNOS-S100A8/9 transnitrosylase complex.
Function	Ezrin-radixin-moesin (ERM) family protein that connects the actin cytoskeleton to the plasma membrane and thereby regulates the structure and function of specific domains of the cell cortex. Tethers actin filaments by oscillating between a resting and an activated state providing transient interactions between moesin and the actin cytoskeleton. Once phosphorylated on its C-terminal threonine, moesin is activated leading to interaction with F-actin and cytoskeletal rearrangement. These rearrangements regulate many cellular processes, including cell shape determination, membrane transport, and signal transduction. The role of moesin is particularly important in immunity acting on both T and B-cells homeostasis and self-tolerance, regulating lymphocyte egress from lymphoid organs. Modulates phagolysosomal biogenesis in macrophages. Participates also in immunologic synapse formation.
Protein Name	Moesin Membrane-Organizing Extension Spike Protein
Database Links	Reactome: R-HSA-437239 Reactome: R-HSA-8950505 Reactome: R-HSA-9662360 Reactome: R-HSA-9662361 Reactome: R-HSA-9725370
Cellular Localisation	Cell Membrane Peripheral Membrane Protein Cytoplasmic Side Cytoplasm Cytoskeleton Apical Cell Membrane Cell Projection Microvillus Membrane Microvillus Phosphorylated Form Is Enriched In Microvilli-Like Structures At Apical Membrane Increased Cell Membrane Localization Of Both Phosphorylated And Non-Phosphorylated Forms Seen After Thrombin Treatment Localizes At The Uropods Of T Lymphoblasts
Alternative ELISA Names	Moesin ELISA kit Membrane-Organizing Extension Spike Protein ELISA kit MSN ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

产品留言

标题

联系人

联系电话

内容

验证码

点击换一张

注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
2.如有必要,请您留下您的详细联系方式!

温馨提示：为规避购买风险，建议您在购买前务必确认供应商资质与产品质量。
免责申明：以上内容为注册会员自行发布，若信息的真实性、合法性存在争议，平台将会监督协助处理，欢迎举报

产品目录

产品资料

Human MSN (Moesin) Sandwich ELISA Kit (STJE0010738)