Anti-BIRC6/Apollon antibody (C-Term) (STJ70295) STJ70295-100 上海玉博生物科技有限公司

Anti-BIRC6/Apollon antibody (C-Term) (STJ70295)

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产品名称：Anti-BIRC6/Apollon antibody (C-Term) (STJ70295)
产品型号：STJ70295-100
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-BIRC6/Apollon antibody (C-Term) (STJ70295)

产品描述

Host:	Goat
Applications:	Pep-ELISA/IHC
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Goat polyclonal antibody anti-BIRC6/Apollon (C-Term) is suitable for use in ELISA and Immunohistochemistry research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	0.5 mg/mL
Dilution Range:	IHC-3.75µg/ml ELISA-antibody detection limit dilution 1:16000.
Storage Instruction:	Store at-20°C on receipt and minimise freeze-thaw cycles.

Gene Symbol:	BIRC6
Gene ID:	57448
Uniprot ID:	BIRC6_HUMAN
Immunogen Region:	C-Term
Accession Number:	NP_057336.3
Immunogen Sequence:	PSSSKELPSDFQL

Post Translational Modifications	Ubiquitinated. Ubiquitination is mediated by the RNF41 E3 ligase and leads to proteasomal degradation, impairing inhibition of apoptosis. Deubiquitinated by USP8/UBPY.
Function	Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its targets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification.
Protein Name	Baculoviral Iap Repeat-Containing Protein 6 Bir Repeat-Containing Ubiquitin-Conjugating Enzyme Bruce Ring-Type E3 Ubiquitin Transferase Birc6 Ubiquitin-Conjugating Bir Domain Enzyme Apollon Apollon
Database Links	Reactome: R-HSA-9700645 Reactome: R-HSA-9725370
Cellular Localisation	Golgi Apparatus Trans-Golgi Network Membrane Endosome Cytoplasm Cytoskeleton Spindle Pole Microtubule Organizing Center Centrosome Midbody Midbody Ring Exhibits Cell Cycle-Dependent Localization Concentrates In A Pericentriolar Compartment In Interphase Moves Partially To Spindle Poles In Metaphase And Finally Localizes To The Spindle Midzone And The Midbody In Telophase And During Cytokinesis On The Midbody Localizes To The Midbody Ring Also Called Flemming Body In Interphase Cells Localizes To The Trans-Golgi Network Membrane And Endosomes During Cytokinesis A Fraction Moves To The Midzone Where It Specifically Arrives At The Midbody Ring After Abscission Completion Travels With The Midbody Remnant Into One Daughter Cell And Remains Bound To It Until A New Midbody Ring Is Formed During The Next Cell Division
Alternative Antibody Names	Anti-Baculoviral Iap Repeat-Containing Protein 6 antibody Anti-Bir Repeat-Containing Ubiquitin-Conjugating Enzyme antibody Anti-Bruce antibody Anti-Ring-Type E3 Ubiquitin Transferase Birc6 antibody Anti-Ubiquitin-Conjugating Bir Domain Enzyme Apollon antibody Anti-Apollon antibody Anti-BIRC6 antibody Anti-KIAA1289 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-BIRC6/Apollon antibody (C-Term) (STJ70295)