Anti-BLNK/SLP-65 antibody (C-Term) (STJ70040) STJ70040-100 上海玉博生物科技有限公司

Anti-BLNK/SLP-65 antibody (C-Term) (STJ70040)

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产品名称：Anti-BLNK/SLP-65 antibody (C-Term) (STJ70040)
产品型号：STJ70040-100
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-BLNK/SLP-65 antibody (C-Term) (STJ70040)

产品描述

Host:	Goat
Applications:	Pep-ELISA/WB/IF/FC
Reactivity:	Human/Mouse/Rat/Dog/Pig/Cow
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Goat polyclonal antibody anti-BLNK/SLP-65 (C-Term) is suitable for use in ELISA, Western Blot, Immunofluorescence and Flow Cytometry research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	0.5 mg/mL
Dilution Range:	WB-Recommended concentration 0.3-1µg/ml IF-Strong expression of the protein seen in the membranes of HepG2 cells. 10µg/ml FC-Flow cytometric analysis of Daudi cells. 10ug/ml ELISA-antibody detection limit dilution 1:32000.
Storage Instruction:	Store at-20°C on receipt and minimise freeze-thaw cycles.

Gene Symbol:	BLNK
Gene ID:	29760
Uniprot ID:	BLNK_HUMAN
Immunogen Region:	C-Term
Accession Number:	NP_037446.1; NP_001107566.1; NP_001245369.1; NP_001245370.1; NP_001245371.1
Specificity:	This antibody is expected to recognize all reported isoforms.
Immunogen Sequence:	KDSTRLKYAVKVS

Post Translational Modifications	Following BCR activation, phosphorylated on tyrosine residues by SYK and LYN. When phosphorylated, serves as a scaffold to assemble downstream targets of antigen activation, including PLCG1, VAV1, GRB2 and NCK1. Phosphorylation of Tyr-84, Tyr-178 and Tyr-189 facilitates PLCG1 binding. Phosphorylation of Tyr-96 facilitates BTK binding. Phosphorylation of Tyr-72 facilitates VAV1 and NCK1 binding. Phosphorylation is required for both Ca(2+) and MAPK signaling pathways.
Function	Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis.
Protein Name	B-Cell Linker Protein B-Cell Adapter Containing A Sh2 Domain Protein B-Cell Adapter Containing A Src Homology 2 Domain Protein Cytoplasmic Adapter Protein Src Homology 2 Domain-Containing Leukocyte Protein Of 65 Kda Slp-65
Database Links	Reactome: R-HSA-912631 Reactome: R-HSA-9679191 Reactome: R-HSA-983695
Cellular Localisation	Cytoplasm Cell Membrane Bcr Activation Results In The Translocation To Membrane Fraction
Alternative Antibody Names	Anti-B-Cell Linker Protein antibody Anti-B-Cell Adapter Containing A Sh2 Domain Protein antibody Anti-B-Cell Adapter Containing A Src Homology 2 Domain Protein antibody Anti-Cytoplasmic Adapter Protein antibody Anti-Src Homology 2 Domain-Containing Leukocyte Protein Of 65 Kda antibody Anti-Slp-65 antibody Anti-BLNK antibody Anti-BASH antibody Anti-SLP65 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-BLNK/SLP-65 antibody (C-Term) (STJ70040)