Anti-BMP1 antibody (284-296) (STJ73107) STJ73107-100 上海玉博生物科技有限公司

Anti-BMP1 antibody (284-296) (STJ73107)

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产品名称：Anti-BMP1 antibody (284-296) (STJ73107)
产品型号：STJ73107-100
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-BMP1 antibody (284-296) (STJ73107)

产品描述

Host:	Goat
Applications:	Pep-ELISA/WB/IHC
Reactivity:	Human/Mouse/Rat/Dog/Pig/Cow
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Goat polyclonal antibody anti-BMP1 (284-296) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	0.5 mg/mL
Dilution Range:	IHC-5µg/ml ELISA-antibody detection limit dilution 1:128000.
Storage Instruction:	Store at-20°C on receipt and minimise freeze-thaw cycles.

Gene Symbol:	BMP1
Gene ID:	649
Uniprot ID:	BMP1_HUMAN
Immunogen Region:	284-296
Accession Number:	NP_001190.1; NP_006120.1
Specificity:	This antibody is expected to recognize both reported isoforms (NP_001190.1; NP_006120.1).
Immunogen Sequence:	DTIVPKYEVNGVK

Post Translational Modifications	Proteolytically activated in the trans-Golgi network by furin-like/paired basic proprotein convertases, cleavage is not required for secretion.
Function	Metalloprotease that plays key roles in regulating the formation of the extracellular matrix (ECM) via processing of various precursor proteins into mature functional enzymes or structural proteins. Thereby participates in several developmental and physiological processes such as cartilage and bone formation, muscle growth and homeostasis, wound healing and tissue repair. Roles in ECM formation include cleavage of the C-terminal propeptides from procollagens such as procollagen I, II and III or the proteolytic activation of the enzyme lysyl oxidase LOX, necessary to formation of covalent cross-links in collagen and elastic fibers. Additional substrates include matricellular thrombospondin-1/THBS1 whose cleavage leads to cell adhesion disruption and TGF-beta activation. Isoform BMP1-3: Plays an important role in bone repair by acting as a coactivator of BMP7.
Protein Name	Bone Morphogenetic Protein 1 Bmp-1 Mammalian Tolloid Protein Mtld Procollagen C-Proteinase Pcp
Database Links	Reactome: R-HSA-1474228 Reactome: R-HSA-1650814 Reactome: R-HSA-2214320 Reactome: R-HSA-2243919 Reactome: R-HSA-8963896 P13497-3
Cellular Localisation	Golgi Apparatus Trans-Golgi Network Secreted Extracellular Space Extracellular Matrix Co-Localizes With Postn In The Golgi Isoform Bmp1-3: Secreted
Alternative Antibody Names	Anti-Bone Morphogenetic Protein 1 antibody Anti-Bmp-1 antibody Anti-Mammalian Tolloid Protein antibody Anti-Mtld antibody Anti-Procollagen C-Proteinase antibody Anti-Pcp antibody Anti-BMP1 antibody Anti-PCOLC antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-BMP1 antibody (284-296) (STJ73107)