Human MYD88 (Myeloid differentiation primary response protein MyD88) CLIA Kit (STJC0000847) STJC0000847 上海玉博生物科技有限公司

Human MYD88 (Myeloid differentiation primary response protein MyD88) CLIA Kit (STJC0000847)

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产品名称：Human MYD88 (Myeloid differentiation primary response protein MyD88) CLIA Kit (STJC0000847)
产品型号：STJC0000847
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human MYD88 (Myeloid differentiation primary response protein MyD88) CLIA Kit (STJC0000847)

产品描述

Applications:	CLIA
Reactivity:	Human
Note:	FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Sensitivity:	18.75pg/mL
Detection Limit:	31.25~2000pg/mL
Short Description:	This human MYD88 kit is a highly sensitive in-vitro chemiluminescent immunoassay for the measurement of trace amounts of analytes.

Storage Instruction:	If unopened the kit may be stored at 2-8°C for up to 1 month. If the kit will not be used within 1 month, store the components separately, according to the component table in the manual.
Assay Time:	3.5h
Detection:	Chemiluminescence

Gene Symbol:	MYD88
Gene ID:	4615
Uniprot ID:	MYD88_HUMAN
Specificity:	This kit recognizes Human MYD88 in samples. No significant cross-reactivity or interference between Human MYD88 and analogues was observed.
Sample Type:	Serum, plasma and other biological fluids

Tissue Specificity	Ubiquitous.
Post Translational Modifications	Ubiquitinated.undergoes 'Lys-63'-linked polyubiquitination. OTUD4 specifically hydrolyzes 'Lys-63'-linked polyubiquitinated MYD88.
Function	Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. Upon TLR8 activation by GU-rich single-stranded RNA (GU-rich RNA) derived from viruses such as SARS-CoV-2, SARS-CoV and HIV-1, induces IL1B release through NLRP3 inflammasome activation. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine.
Protein Name	Myeloid Differentiation Primary Response Protein Myd88
Database Links	Reactome: R-HSA-1236974 Reactome: R-HSA-1257604 Reactome: R-HSA-166058 Reactome: R-HSA-1810476 Reactome: R-HSA-209543 Reactome: R-HSA-3134963 Reactome: R-HSA-5602498 Reactome: R-HSA-5602680 Reactome: R-HSA-5603037 Reactome: R-HSA-5603041 Reactome: R-HSA-6811558 Reactome: R-HSA-9020702 Reactome: R-HSA-975110 Reactome: R-HSA-975138 Reactome: R-HSA-975155 Reactome: R-HSA-975871
Cellular Localisation	Cytoplasm Nucleus
Alternative CLIA Names	Myeloid Differentiation Primary Response Protein Myd88 CLIA kit MYD88 CLIA kit
Specificity	This kit recognizes Human MYD88 in samples. No significant cross-reactivity or interference between Human MYD88 and analogues was observed.
Reproducibility	Both intra-CV and inter-CV are

Information sourced from Uniprot.org

Item Specifications Storage

Micro CLIA Plate (Dismountable)	96T: 8 wells ×12 strips strips	-20℃, 6 months
Reference Standard	96T: 2 vials 48T: 1 vial	-20℃, 6 months
Concentrated Biotinylated Detection Ab (100×)	96T: 1 vial, 120 μL 60 μL	-20℃, 6 months
Concentrated HRP Conjugate (100×)	96T: 1 vial, 120 μL 60 μL	-20℃ (Protect from light), 6 months
Reference Standard & Sample Diluent	1 vial, 20 mL	2-8°C, 6 months
Biotinylated Detection Ab Diluent	1 vial, 14 mL	2-8°C, 6 months
HRP Conjugate Diluent	1 vial, 14 mL	2-8°C, 6 months
Concentrated Wash Buffer (25×)	1 vial, 30 mL	2-8°C, 6 months
Substrate Reagent A	1 vial, 5 mL	2-8℃ (Protect from light)
Substrate Reagent B	1 vial, 5 mL	2-8℃ (Protect from light)
Plate Sealer	5 pieces
Manual	1 copy
Certificate of Analysis	1 copy

Sample Type Range (%) Average Recovery (%)

Serum(n=8)	86-99	92
EDTA plasma(n=8)	89-103	95
Cell culture media(n=8)	98-114	104

Intra-assay Precision Intra-assay Precision Intra-assay Precision Inter-assay Precision Inter-assay Precision Inter-assay Precision

Sample	1.00	2.00	3.00	1.00	2.00	3.00
n	20.00	20.00	20.00	20.00	20.00	20.00
Mean (pg/mL)	104.53	248.23	748.33	95.07	270.56	770.56
Standard deviation	10.89	24.18	79.10	8.08	23.32	75.44
CV (%)	10.42	9.74	10.57	8.50	8.62	9.79

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human MYD88 (Myeloid differentiation primary response protein MyD88) CLIA Kit (STJC0000847)