Human MYO10 (Myosin X) Competitive ELISA Kit (STJE0010846) STJE0010846 上海玉博生物科技有限公司

Human MYO10 (Myosin X) Competitive ELISA Kit (STJE0010846)

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产品名称：Human MYO10 (Myosin X) Competitive ELISA Kit (STJE0010846)
产品型号：STJE0010846
产品展商：ST john's laboratory
产品文档：无相关文档

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Human MYO10 (Myosin X) Competitive ELISA Kit (STJE0010846)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.114ng/mL
Detection Limit:	0.312-20ng/mL
Short Description:	This MYO10 Competitive ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	2.5 hrs

Gene Symbol:	MYO10
Gene ID:	4651
Uniprot ID:	MYO10_HUMAN
Sample Type:	serum, plasma, tissue homogenates or other biological fluids.

Tissue Specificity	Ubiquitous.
Post Translational Modifications	The initiator methionine for isoform Headless is removed.
Function	Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as a plus end-directed motor. Moves with higher velocity and takes larger steps on actin bundles than on single actin filaments. The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. In hippocampal neurons it induces the formation of dendritic filopodia by trafficking the actin-remodeling protein VASP to the tips of filopodia, where it promotes actin elongation. Plays a role in formation of the podosome belt in osteoclasts. Isoform Headless: Functions as a dominant-negative regulator of isoform 1, suppressing its filopodia-inducing and axon outgrowth-promoting activities. In hippocampal neurons, it increases VASP retention in spine heads to induce spine formation and spine head expansion.
Protein Name	Unconventional Myosin-X Unconventional Myosin-10
Database Links	Reactome: R-HSA-2029482 Reactome: R-HSA-373752 Reactome: R-HSA-9664422
Cellular Localisation	Cytoplasm Cytosol Cell Projection Lamellipodium Ruffle Cytoskeleton Filopodium Tip Cell Cortex Filopodium Membrane Peripheral Membrane Protein May Be In An Inactive Monomeric Conformation In The Cytosol Detected In Cytoplasmic Punctae And In Cell Projections Colocalizes With Actin Fibers Undergoes Forward And Rearward Movements Within Filopodia Interacts With Microtubules
Alternative ELISA Names	Unconventional Myosin-X ELISA kit Unconventional Myosin-10 ELISA kit MYO10 ELISA kit KIAA0799 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human MYO10 (Myosin X) Competitive ELISA Kit (STJE0010846)