Anti-CD31/PECAM1 antibody [158-2B3] {PE} (STJA0002655) STJA0002655 上海玉博生物科技有限公司

Anti-CD31/PECAM1 antibody [158-2B3] {PE} (STJA0002655)

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产品名称：Anti-CD31/PECAM1 antibody [158-2B3] {PE} (STJA0002655)
产品型号：STJA0002655
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CD31/PECAM1 antibody [158-2B3] {PE} (STJA0002655)

产品描述

Host:	Mouse
Applications:	FC
Reactivity:	Human
Note:	FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description:	Mouse monoclonal antibody anti-Platelet endothelial cell adhesion molecule is suitable for use in Flow Cytometry research applications.

Clonality:	Monoclonal
Clone ID:	158-2B3
Conjugation:	PE
Isotype:	IgG1k
Formulation:	PBS with 0.05% Proclin300, 1% BSA
Storage Instruction:	Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product.

Gene Symbol:	PECAM1
Gene ID:	5175
Uniprot ID:	PECA1_HUMAN

Tissue Specificity	Expressed on platelets and leukocytes and is primarily concentrated at the borders between endothelial cells. Expressed in human umbilical vein endothelial cells (HUVECs) (at protein level). Expressed on neutrophils (at protein level). Isoform Long predominates in all tissues examined. Isoform Delta12 is detected only in trachea. Isoform Delta14-15 is only detected in lung. Isoform Delta14 is detected in all tissues examined with the strongest expression in heart. Isoform Delta15 is expressed in brain, testis, ovary, cell surface of platelets, human umbilical vein endothelial cells (HUVECs), Jurkat T-cell leukemia, human erythroleukemia (HEL) and U-937 histiocytic lymphoma cell lines (at protein level).
Post Translational Modifications	Phosphorylated on Ser and Tyr residues after cellular activation by src kinases. Upon activation, phosphorylated on Ser-729 which probably initiates the dissociation of the membrane-interaction segment (residues 709-729) from the cell membrane allowing the sequential phosphorylation of Tyr-713 and Tyr-690. Constitutively phosphorylated on Ser-734 in resting platelets. Phosphorylated on tyrosine residues by FER and FES in response to FCER1 activation. In endothelial cells Fyn mediates mechanical-force (stretch or pull) induced tyrosine phosphorylation. Palmitoylation by ZDHHC21 is necessary for cell surface expression in endothelial cells and enrichment in membrane rafts.
Function	Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions. Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils. Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal. Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells.PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes. Modulates bradykinin receptor BDKRB2 activation. Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells. Induces susceptibility to atherosclerosis. Isoform Delta15: Does not protect against apoptosis.
Protein Name	Platelet Endothelial Cell Adhesion Molecule Pecam-1 Endocam Gpiia' Peca1 Cd Antigen Cd31
Database Links	Reactome: R-HSA-114608 Reactome: R-HSA-202733 Reactome: R-HSA-210990 Reactome: R-HSA-216083 Reactome: R-HSA-432142 Reactome: R-HSA-6798695
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein Cell Surface Expression On Neutrophils Is Down-Regulated Upon Fmlp Or Cxcl8/Il8-Mediated Stimulation Isoform Long: Cell Membrane Membrane Raft Cell Junction Localizes To The Lateral Border Recycling Compartment (Lbrc) And Recycles From The Lbrc To The Junction In Resting Endothelial Cells Isoform Delta15: Cell Junction
Alternative Antibody Names	Anti-Platelet Endothelial Cell Adhesion Molecule antibody Anti-Pecam-1 antibody Anti-Endocam antibody Anti-Gpiia' antibody Anti-Peca1 antibody Anti-Cd Antigen Cd31 antibody Anti-PECAM1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CD31/PECAM1 antibody [158-2B3] {PE} (STJA0002655)