Anti-CD33 antibody [6C5] {AF488} (STJA0002682) STJA0002682 上海玉博生物科技有限公司

Anti-CD33 antibody [6C5] {AF488} (STJA0002682)

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产品名称：Anti-CD33 antibody [6C5] {AF488} (STJA0002682)
产品型号：STJA0002682
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CD33 antibody [6C5] {AF488} (STJA0002682)

产品描述

Host:	Mouse
Applications:	FC
Reactivity:	Human
Note:	FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description:	Mouse monoclonal antibody anti-Myeloid cell surface antigen CD33 is suitable for use in Flow Cytometry research applications.

Clonality:	Monoclonal
Clone ID:	6C5
Conjugation:	AF488
Isotype:	IgG1k
Formulation:	PBS with 0.05% Proclin300, 1% BSA
Storage Instruction:	Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product.

Gene Symbol:	CD33
Gene ID:	945
Uniprot ID:	CD33_HUMAN

Tissue Specificity	Monocytic/myeloid lineage cells. In the brain, CD33 is mainly expressed on microglial cells.
Post Translational Modifications	Glycosylated. Glycosylation at Asn-100 is critical for regulating ligand recognition. Phosphorylation of Tyr-340 is involved in binding to PTPN6 and PTPN11. Phosphorylation of Tyr-358 is involved in binding to PTPN6. LCK phosphorylates Tyr-340 efficiently and Tyr-358 to a lesser extent.
Function	Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state. Preferentially recognizes and binds alpha-2,3- and more avidly alpha-2,6-linked sialic acid-bearing glycans. Upon engagement of ligands such as C1q or syalylated glycoproteins, two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) located in CD33 cytoplasmic tail are phosphorylated by Src-like kinases such as LCK. These phosphorylations provide docking sites for the recruitment and activation of protein-tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2. In turn, these phosphatases regulate downstream pathways through dephosphorylation of signaling molecules. One of the repressive effect of CD33 on monocyte activation requires phosphoinositide 3-kinase/PI3K.
Protein Name	Myeloid Cell Surface Antigen Cd33 Sialic Acid-Binding Ig-Like Lectin 3 Siglec-3 Gp67 Cd Antigen Cd33
Database Links	Reactome: R-HSA-198933 Reactome: R-HSA-6798695
Cellular Localisation	Isoform Cd33m: Cell Membrane Single-Pass Type I Membrane Protein Isoform Cd33m: Peroxisome Cd33m Isoform Does Not Localize To Cell Surfaces But Instead Accumulates In Peroxisomes
Alternative Antibody Names	Anti-Myeloid Cell Surface Antigen Cd33 antibody Anti-Sialic Acid-Binding Ig-Like Lectin 3 antibody Anti-Siglec-3 antibody Anti-Gp67 antibody Anti-Cd Antigen Cd33 antibody Anti-CD33 antibody Anti-SIGLEC3 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CD33 antibody [6C5] {AF488} (STJA0002682)