Anti-BMP2 antibody (45-60) {Biotin} (STJ500273) STJ500273-100 上海玉博生物科技有限公司

Anti-BMP2 antibody (45-60) {Biotin} (STJ500273)

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产品名称：Anti-BMP2 antibody (45-60) {Biotin} (STJ500273)
产品型号：STJ500273-100
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-BMP2 antibody (45-60) {Biotin} (STJ500273)

产品描述

Host:	Rabbit
Applications:	CM/ELISA/ICC/IF/IHC/IP/WB
Reactivity:	Human/Monkey/Mouse/Pig
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-BMP2 (45-60) is suitable for use in Confocal Microscopy, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Biotin
Isotype:	IgG
Purification:	Affinity Purified
Concentration:	0.729 µg/µl
Dilution Range:	WB: 1:500-1:, 1000 DB: 1:2, 000 ELISA: 1:2, 000 IP: 1:200 IHC: 1:200 ICC: 1:200 IF: 1:200 CFM: 1:200
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	Bmp2
Gene ID:	12156
Uniprot ID:	BMP2_MOUSE
Immunogen Region:	45-60
Immunogen:	Synthetic peptide corresponding to Mouse BMP2 amino acid region 45-60 conjugated to Keyhole Limpet Haemocyanin (KLH).

Function	Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cardiogenesis, neurogenesis, and osteogenesis. Induces cartilage and bone formation. Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. Also acts to promote expression of HAMP, via the interaction with its receptor BMPR1A/ALK3. Can also signal through non-canonical pathways such as ERK/MAP kinase signaling cascade that regulates osteoblast differentiation. Also stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A-ATF4 pathway by stimulating EIF2A phosphorylation which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, expression is repressed during the bell stage by MSX1-mediated inhibition of CTNNB1 signaling.
Protein Name	Bone Morphogenetic Protein 2 Bmp-2 Bone Morphogenetic Protein 2a Bmp-2a
Database Links	Reactome: R-MMU-201451 Reactome: -MMU-2129379
Cellular Localisation	Secreted
Alternative Antibody Names	Anti-Bone Morphogenetic Protein 2 antibody Anti-Bmp-2 antibody Anti-Bone Morphogenetic Protein 2a antibody Anti-Bmp-2a antibody Anti-Bmp2 antibody Anti-Bmp-2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-BMP2 antibody (45-60) {Biotin} (STJ500273)