Anti-BMP4 antibody (Internal) (STJ73557) STJ73557-100 上海玉博生物科技有限公司

Anti-BMP4 antibody (Internal) (STJ73557)

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产品名称：Anti-BMP4 antibody (Internal) (STJ73557)
产品型号：STJ73557-100
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-BMP4 antibody (Internal) (STJ73557)

产品描述

Host:	Goat
Applications:	Pep-ELISA/WB
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Goat polyclonal antibody anti-BMP4 (Internal) is suitable for use in ELISA and Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	0.5 mg/mL
Dilution Range:	WB-0.3-1µg/ml ELISA-antibody detection limit dilution 1:64000.
Storage Instruction:	Store at-20°C on receipt and minimise freeze-thaw cycles.

Gene Symbol:	BMP4
Gene ID:	652
Uniprot ID:	BMP4_HUMAN
Immunogen Region:	Internal
Accession Number:	NP_001193.2
Specificity:	The immunizing peptide represents the N terminus of the mature protein. Reported variants represent identical protein: NP_570911.2, NP_001193.2, NP_570912.2.
Immunogen Sequence:	SPKHHSQRARK

Function	Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including neurogenesis, vascular development, angiogenesis and osteogenesis. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction. Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. Positively regulates the expression of odontogenic development regulator MSX1 via inducing the IPO7-mediated import of SMAD1 to the nucleus. Required for MSX1-mediated mesenchymal molar tooth bud development beyond the bud stage, via promoting Wnt signaling. Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, expression is repressed during the bell stage by MSX1-mediated inhibition of CTNNB1 signaling. Able to induce its own expression in dental mesenchymal cells and also in the neighboring dental epithelial cells via an MSX1-mediated pathway. Can also signal through non-canonical BMP pathways such as ERK/MAP kinase, PI3K/Akt, or SRC cascades. For example, induces SRC phosphorylation which, in turn, activates VEGFR2, leading to an angiogenic response.
Protein Name	Bone Morphogenetic Protein 4 Bmp-4 Bone Morphogenetic Protein 2b Bmp-2b
Database Links	Reactome: R-HSA-2129379 Reactome: R-HSA-381426 Reactome: R-HSA-8957275 Reactome: R-HSA-9754189 Reactome: R-HSA-9758920 Reactome: R-HSA-9761174 Reactome: R-HSA-9793380 Reactome: R-HSA-9827857
Cellular Localisation	Secreted Extracellular Space Extracellular Matrix
Alternative Antibody Names	Anti-Bone Morphogenetic Protein 4 antibody Anti-Bmp-4 antibody Anti-Bone Morphogenetic Protein 2b antibody Anti-Bmp-2b antibody Anti-BMP4 antibody Anti-BMP2B antibody Anti-DVR4 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-BMP4 antibody (Internal) (STJ73557)