Anti-BMP7 antibody (120-131) (STJ73558) STJ73558-100 上海玉博生物科技有限公司

Anti-BMP7 antibody (120-131) (STJ73558)

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产品名称：Anti-BMP7 antibody (120-131) (STJ73558)
产品型号：STJ73558-100
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-BMP7 antibody (120-131) (STJ73558)

产品描述

Host:	Goat
Applications:	Pep-ELISA/WB
Reactivity:	Human/Mouse/Rat/Dog/Pig/Cow
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Goat polyclonal antibody anti-BMP7 (120-131) is suitable for use in ELISA and Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	0.5 mg/mL
Dilution Range:	WB-1-3µg/ml ELISA-antibody detection limit dilution 1:2000.
Storage Instruction:	Store at-20°C on receipt and minimise freeze-thaw cycles.

Gene Symbol:	BMP7
Gene ID:	655
Uniprot ID:	BMP7_HUMAN
Immunogen Region:	120-131
Accession Number:	NP_001710.1
Specificity:	This antibody is expected to recognize precursor only.
Immunogen Sequence:	SLQDSHFLTDAD

Post Translational Modifications	Several N-termini starting at positions 293, 300, 315 and 316 have been identified by direct sequencing resulting in secretion of different mature forms.
Function	Growth factor of the TGF-beta superfamily that plays important role in various biological processes, including embryogenesis, hematopoiesis, neurogenesis and skeletal morphogenesis. Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2A. Once all three components are bound together in a complex at the cell surface, ACVR2A phosphorylates and activates ACVR1. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. For specific functions such as growth cone collapse in developing spinal neurons and chemotaxis of monocytes, uses also BMPR2 as type II receptor. Can also signal through non-canonical pathways such as P38 MAP kinase signaling cascade that promotes brown adipocyte differentiation through activation of target genes, including members of the SOX family of transcription factors. Promotes the expression of HAMP, this is repressed by its interaction with ERFE.
Protein Name	Bone Morphogenetic Protein 7 Bmp-7 Osteogenic Protein 1 Op-1 Eptotermin Alfa
Database Links	Reactome: R-HSA-2129379
Cellular Localisation	Secreted
Alternative Antibody Names	Anti-Bone Morphogenetic Protein 7 antibody Anti-Bmp-7 antibody Anti-Osteogenic Protein 1 antibody Anti-Op-1 antibody Anti-Eptotermin Alfa antibody Anti-BMP7 antibody Anti-OP1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-BMP7 antibody (120-131) (STJ73558)