Human NCCT (Na-Cl Cotransporter) Sandwich ELISA Kit Ready-To-Use (STJE0017273) STJE0017273 上海玉博生物科技有限公司

Human NCCT (Na-Cl Cotransporter) Sandwich ELISA Kit Ready-To-Use (STJE0017273)

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产品名称：Human NCCT (Na-Cl Cotransporter) Sandwich ELISA Kit Ready-To-Use (STJE0017273)
产品型号：STJE0017273
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human NCCT (Na-Cl Cotransporter) Sandwich ELISA Kit Ready-To-Use (STJE0017273)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.123ng/mL
Detection Limit:	0.312-20ng/mL
Short Description:	This NCCT Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	3 hrs

Gene Symbol:	SLC12A3
Gene ID:	6559
Uniprot ID:	S12A3_HUMAN
Immunogen Region:	Ready-To-Use
Sample Type:	tissue homogenates, cell lysates or other biological fluids.

Tissue Specificity	Predominantly expressed in the kidney (at protein level). Localizes to the distal convoluted tubules (at protein level). Not detected in normal aorta, but abundantly expressed in fatty streaks and advanced atherosclerotic lesions (at protein level).
Post Translational Modifications	Ubiquitinated.ubiquitination is essential for regulation of endocytosis. The BCR(KLHL3) complex was initially identified as a candidate ubiquitin ligase for SLC12A3. However, it was later shown that it is not the case. Phosphorylated at Thr-46, Thr-55, Thr-60 and Ser-91 by OXSR1/OSR1 and STK39/SPAK downstream of WNK4, promoting its activity. Phosphorylated in response to IL18.
Function	Electroneutral sodium and chloride ion cotransporter, which acts as a key mediator of sodium and chloride reabsorption in kidney distal convoluted tubules. Also acts as a receptor for the pro-inflammatory cytokine IL18, thereby contributing to IL18-induced cytokine production, including IFNG, IL6, IL18 and CCL2. May act either independently of IL18R1, or in a complex with IL18R1.
Protein Name	Solute Carrier Family 12 Member 3 Na-Cl Cotransporter Ncc Na-Cl Symporter Thiazide-Sensitive Sodium-Chloride Cotransporter
Database Links	Reactome: R-HSA-426117 Reactome: R-HSA-5619087
Cellular Localisation	Cell Membrane Multi-Pass Membrane Protein Apical Cell Membrane
Alternative ELISA Names	Solute Carrier Family 12 Member 3 ELISA kit Na-Cl Cotransporter ELISA kit Ncc ELISA kit Na-Cl Symporter ELISA kit Thiazide-Sensitive Sodium-Chloride Cotransporter ELISA kit SLC12A3 ELISA kit NCC ELISA kit TSC ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human NCCT (Na-Cl Cotransporter) Sandwich ELISA Kit Ready-To-Use (STJE0017273)