Human NCOA3 (Nuclear Receptor Coactivator 3) Sandwich ELISA Kit Ready-To-Use (STJE0017280) STJE0017280 上海玉博生物科技有限公司

Human NCOA3 (Nuclear Receptor Coactivator 3) Sandwich ELISA Kit Ready-To-Use (STJE0017280)

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产品名称：Human NCOA3 (Nuclear Receptor Coactivator 3) Sandwich ELISA Kit Ready-To-Use (STJE0017280)
产品型号：STJE0017280
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human NCOA3 (Nuclear Receptor Coactivator 3) Sandwich ELISA Kit Ready-To-Use (STJE0017280)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.117ng/mL
Detection Limit:	0.312-20ng/mL
Short Description:	This NCOA3 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	3 hrs

Gene Symbol:	NCOA3
Gene ID:	8202
Uniprot ID:	NCOA3_HUMAN
Immunogen Region:	Ready-To-Use
Sample Type:	tissue homogenates, cell lysates or other biological fluids.

Tissue Specificity	Widely expressed. High expression in heart, skeletal muscle, pancreas and placenta. Low expression in brain, and very low in lung, liver and kidney.
Post Translational Modifications	Acetylated by CREBBP. Acetylation occurs in the RID domain, and disrupts the interaction with nuclear receptors and regulates its function. Methylated by CARM1. Phosphorylated by IKK complex. Regulated its function. Phosphorylation at Ser-601 by CK1 promotes coactivator function.
Function	Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit.
Protein Name	Nuclear Receptor Coactivator 3 Ncoa-3 Actr Amplified In Breast Cancer 1 Protein Aib-1 Cbp-Interacting Protein Pcip Class E Basic Helix-Loop-Helix Protein 42 Bhlhe42 Receptor-Associated Coactivator 3 Rac-3 Steroid Receptor Coactivator Protein 3 Src-3 Thyroid Hormone Receptor Activator Molecule 1 Tram-1
Database Links	Reactome: R-HSA-1989781 Reactome: R-HSA-381340 Reactome: R-HSA-5617472 Reactome: R-HSA-5687128 Reactome: R-HSA-9018519
Cellular Localisation	Cytoplasm Nucleus Mainly Cytoplasmic And Weakly Nuclear Upon Tnf Activation And Subsequent Phosphorylation It Translocates From The Cytoplasm To The Nucleus
Alternative ELISA Names	Nuclear Receptor Coactivator 3 ELISA kit Ncoa-3 ELISA kit Actr ELISA kit Amplified In Breast Cancer 1 Protein ELISA kit Aib-1 ELISA kit Cbp-Interacting Protein ELISA kit Pcip ELISA kit Class E Basic Helix-Loop-Helix Protein 42 ELISA kit Bhlhe42 ELISA kit Receptor-Associated Coactivator 3 ELISA kit Rac-3 ELISA kit Steroid Receptor Coactivator Protein 3 ELISA kit Src-3 ELISA kit Thyroid Hormone Receptor Activator Molecule 1 ELISA kit Tram-1 ELISA kit NCOA3 ELISA kit AIB1 ELISA kit BHLHE42 ELISA kit RAC3 ELISA kit TRAM1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human NCOA3 (Nuclear Receptor Coactivator 3) Sandwich ELISA Kit Ready-To-Use (STJE0017280)