Anti-BNIP1 antibody (Internal) (STJ71277) STJ71277-100 上海玉博生物科技有限公司

Anti-BNIP1 antibody (Internal) (STJ71277)

简单介绍

Anti-BNIP1 antibody (Internal) (STJ71277)

产品描述

Host:	Goat
Applications:	Pep-ELISA/WB
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Goat polyclonal antibody anti-BNIP1 (Internal) is suitable for use in ELISA and Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	0.5 mg/mL
Dilution Range:	WB-0.5-1.5µg/ml ELISA-antibody detection limit dilution 1:8000.
Storage Instruction:	Store at-20°C on receipt and minimise freeze-thaw cycles.

Gene Symbol:	BNIP1
Gene ID:	662
Uniprot ID:	SEC20_HUMAN
Immunogen Region:	Internal
Accession Number:	NP_001196.1; NP_053581.1; NP_053582.1; NP_053583.1
Specificity:	All reported variants represent isoform 1 (NP_001196.1; NP_053581.1; NP_053582.1; NP_053583.1)
Immunogen Sequence:	DLLRQRKTTKESLAQ

Post Translational Modifications	Polyubiquitinated. 'Lys-63'-linked polyubiquitination by RNF185 increases the interaction with the autophagy receptor SQSTM1. Undergoes 'Lys-29'- and 'Lys-63'-linked polyubiquitination by RNF186 that may regulate BNIP1 localization to the mitochondrion.
Function	As part of a SNARE complex may be involved in endoplasmic reticulum membranes fusion and be required for the maintenance of endoplasmic reticulum organization. Also plays a role in apoptosis. It is for instance required for endoplasmic reticulum stress-induced apoptosis. As a substrate of RNF185 interacting with SQSTM1, might also be involved in mitochondrial autophagy (Probable).
Protein Name	Vesicle Transport Protein Sec20 Bcl2/Adenovirus E1b 19 Kda Protein-Interacting Protein 1 Transformation-Related Gene 8 Protein Trg-8
Database Links	Reactome: R-HSA-6811434
Cellular Localisation	Endoplasmic Reticulum Membrane Single-Pass Type Iv Membrane Protein Mitochondrion Membrane Localization To The Mitochondrion Is Regulated By Rnf186
Alternative Antibody Names	Anti-Vesicle Transport Protein Sec20 antibody Anti-Bcl2/Adenovirus E1b 19 Kda Protein-Interacting Protein 1 antibody Anti-Transformation-Related Gene 8 Protein antibody Anti-Trg-8 antibody Anti-BNIP1 antibody Anti-NIP1 antibody Anti-SEC20L antibody Anti-TRG8 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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