Anti-BNIP3 antibody (40-120) [S4836RM] (STJ11104836) STJ11104836 上海玉博生物科技有限公司

Anti-BNIP3 antibody (40-120) [S4836RM] (STJ11104836)

简单介绍

Anti-BNIP3 antibody (40-120) [S4836RM] (STJ11104836)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit monoclonal antibody anti-Bcl2/Adenovirus E1b 19 Kda Protein-Interacting Protein 3 (40-120) is suitable for use in Western Blot research applications.

Clonality:	Monoclonal
Clone ID:	S4836RM
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	BNIP3
Gene ID:	664
Uniprot ID:	BNIP3_HUMAN
Immunogen Region:	40-120
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 40-120 of human BNIP3 (NP_004043.3).
Immunogen Sequence:	AFPPPAAEAHPAARRGLRSP QLPSGAMSQNGAPGMQEESL QGSWVELHFSNNGNGGSVPA SVSIYNGDMEKILLDAQHES G

Function	Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway.
Protein Name	Bcl2/Adenovirus E1b 19 Kda Protein-Interacting Protein 3
Cellular Localisation	Mitochondrion Mitochondrion Outer Membrane Single-Pass Membrane Protein Coexpression With The Eib 19-Kda Protein Results In A Shift In Nip3 Localization Pattern To The Nuclear Envelope Colocalizes With Acaa2 In The Mitochondria Colocalizes With Spata18 At The Mitochondrion Outer Membrane
Alternative Antibody Names	Anti-Bcl2/Adenovirus E1b 19 Kda Protein-Interacting Protein 3 antibody Anti-BNIP3 antibody Anti-NIP3 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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