Human NEIL1 (Nei Endonuclease VIII Like Protein 1) Sandwich ELISA Kit (STJE0010911) STJE0010911 上海玉博生物科技有限公司

Human NEIL1 (Nei Endonuclease VIII Like Protein 1) Sandwich ELISA Kit (STJE0010911)

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产品名称：Human NEIL1 (Nei Endonuclease VIII Like Protein 1) Sandwich ELISA Kit (STJE0010911)
产品型号：STJE0010911
产品展商：ST john's laboratory
产品文档：无相关文档

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Human NEIL1 (Nei Endonuclease VIII Like Protein 1) Sandwich ELISA Kit (STJE0010911)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.062ng/mL
Detection Limit:	0.156-10ng/mL
Short Description:	This NEIL1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	NEIL1
Gene ID:	79661
Uniprot ID:	NEIL1_HUMAN
Sample Type:	tissue homogenates or other biological fluids.

Tissue Specificity	Ubiquitous.
Post Translational Modifications
Function	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.
Protein Name	Endonuclease 8-Like 1 Dna Glycosylase/Ap Lyase Neil1 Dna-(Apurinic Or Apyrimidinic Site Lyase Neil1 Endonuclease Viii-Like 1 Fpg1 Nei Homolog 1 Neh1 Nei-Like Protein 1
Database Links	Reactome: R-HSA-110328 Reactome: R-HSA-110329 Reactome: R-HSA-5649702 Reactome: R-HSA-9616334
Cellular Localisation	Cytoplasm Cytoskeleton Microtubule Organizing Center Centrosome Nucleus Chromosome During Mitosis Associates With Centrosomes And Condensed Chromatin
Alternative ELISA Names	Endonuclease 8-Like 1 ELISA kit Dna Glycosylase/Ap Lyase Neil1 ELISA kit Dna-(Apurinic Or Apyrimidinic Site Lyase Neil1 ELISA kit Endonuclease Viii-Like 1 ELISA kit Fpg1 ELISA kit Nei Homolog 1 ELISA kit Neh1 ELISA kit Nei-Like Protein 1 ELISA kit NEIL1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human NEIL1 (Nei Endonuclease VIII Like Protein 1) Sandwich ELISA Kit (STJE0010911)