Human NEIL3 (Nei Endonuclease VIII Like Protein 3) Sandwich ELISA Kit (STJE0010912) STJE0010912 上海玉博生物科技有限公司

Human NEIL3 (Nei Endonuclease VIII Like Protein 3) Sandwich ELISA Kit (STJE0010912)

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产品名称：Human NEIL3 (Nei Endonuclease VIII Like Protein 3) Sandwich ELISA Kit (STJE0010912)
产品型号：STJE0010912
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human NEIL3 (Nei Endonuclease VIII Like Protein 3) Sandwich ELISA Kit (STJE0010912)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	34.55pg/mL
Detection Limit:	78.1-5000pg/mL
Short Description:	This NEIL3 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	NEIL3
Gene ID:	55247
Uniprot ID:	NEIL3_HUMAN
Sample Type:	tissue homogenates, cell lysates or other biological fluids.

Tissue Specificity	Expressed in keratinocytes and embryonic fibroblasts (at protein level). Also detected in thymus, testis and fetal lung primary fibroblasts.
Post Translational Modifications
Function	DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA). Mediates interstrand cross-link repair in response to replication stress: acts by mediating DNA glycosylase activity, cleaving one of the two N-glycosyl bonds comprising the interstrand cross-link, which avoids the formation of a double-strand break but generates an abasic site that is bypassed by translesion synthesis polymerases. In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA.also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5-OHMH, Tg and 8-oxoA lesions in ssDNA. No activity on 8-oxoG detected. Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity. In vivo, appears to be the primary enzyme involved in removing Sp and Gh from ssDNA in neonatal tissues.
Protein Name	Endonuclease 8-Like 3 Dna Glycosylase Fpg2 Dna Glycosylase/Ap Lyase Neil3 Endonuclease Viii-Like 3 Nei-Like Protein 3
Database Links	Reactome: R-HSA-110328 Reactome: R-HSA-110329 Reactome: R-HSA-110330 Reactome: R-HSA-110331 Reactome: R-HSA-9629232 Reactome: R-HSA-9636003
Cellular Localisation	Nucleus Chromosome Recruited To Replication Stress Sites Via Interaction With Ubiquitinated Cmg Helicase
Alternative ELISA Names	Endonuclease 8-Like 3 ELISA kit Dna Glycosylase Fpg2 ELISA kit Dna Glycosylase/Ap Lyase Neil3 ELISA kit Endonuclease Viii-Like 3 ELISA kit Nei-Like Protein 3 ELISA kit NEIL3 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human NEIL3 (Nei Endonuclease VIII Like Protein 3) Sandwich ELISA Kit (STJE0010912)