Anti-BOK antibody (Internal) (STJ72368) STJ72368-100 上海玉博生物科技有限公司

Anti-BOK antibody (Internal) (STJ72368)

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产品名称：Anti-BOK antibody (Internal) (STJ72368)
产品型号：STJ72368-100
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-BOK antibody (Internal) (STJ72368)

产品描述

Host:	Goat
Applications:	Pep-ELISA/IHC
Reactivity:	Human/Mouse/Cow
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Goat polyclonal antibody anti-BOK (Internal) is suitable for use in ELISA and Immunohistochemistry research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	0.5 mg/mL
Dilution Range:	IHC-5µg/ml ELISA-antibody detection limit dilution 1:8000.
Storage Instruction:	Store at-20°C on receipt and minimise freeze-thaw cycles.

Gene Symbol:	BOK
Gene ID:	666
Uniprot ID:	BOK_HUMAN
Immunogen Region:	Internal
Accession Number:	NP_115904.1
Immunogen Sequence:	HISLQSEPVVTD

Post Translational Modifications	Ubiquitinated by AMFR/gp78 E3 ubiquitin ligase complex.mediates degradation by ubiquitin-proteasome pathway in a VCP/p97-dependent manner.prevents from pro-apoptotic activity.promotes degradation of newly synthesized proteins that are not ITPR1 associated.
Function	Isoform 1: Apoptosis regulator that functions through different apoptotic signaling pathways. Plays a roles as pro-apoptotic protein that positively regulates intrinsic apoptotic process in a BAX- and BAK1-dependent manner or in a BAX- and BAK1-independent manner. In response to endoplasmic reticulum stress promotes mitochondrial apoptosis through downstream BAX/BAK1 activation and positive regulation of PERK-mediated unfolded protein response. Activates apoptosis independently of heterodimerization with survival-promoting BCL2 and BCL2L1 through induction of mitochondrial outer membrane permeabilization, in a BAX- and BAK1-independent manner, in response to inhibition of ERAD-proteasome degradation system, resulting in cytochrome c release. In response to DNA damage, mediates intrinsic apoptotic process in a TP53-dependent manner. Plays a role in granulosa cell apoptosis by CASP3 activation. Plays a roles as anti-apoptotic protein during neuronal apoptotic process, by negatively regulating poly ADP-ribose polymerase-dependent cell death through regulation of neuronal calcium homeostasis and mitochondrial bioenergetics in response to NMDA excitation. In addition to its role in apoptosis, may regulate trophoblast cell proliferation during the early stages of placental development, by acting on G1/S transition through regulation of CCNE1 expression. May also play a role as an inducer of autophagy by disrupting interaction between MCL1 and BECN1. Isoform 2: Pro-apoptotic molecule exerting its function through the mitochondrial pathway.
Protein Name	Bcl-2-Related Ovarian Killer Protein Hbok Bcl-2-Like Protein 9 Bcl2-L-9
Cellular Localisation	Isoform 1: Mitochondrion Membrane Single-Pass Membrane Protein Endoplasmic Reticulum Membrane Mitochondrion Inner Membrane Cytoplasm Nucleus Mitochondrion Endoplasmic Reticulum Mitochondrion Outer Membrane Early Endosome Membrane Recycling Endosome Membrane Nucleus Outer Membrane Golgi Apparatus Cis-Golgi Network Membrane Trans-Golgi Network Membrane Membrane Nuclear And Cytoplasmic Compartments In The Early Stages Of Apoptosis And During Apoptosis It Associates With Mitochondria In Healthy Cells Associates Loosely With The Membrane In A Hit-And-Run Mode The Insertion And Accumulation On Membranes Is Enhanced Through The Activity Of Death Signals Resulting In The Integration Of The Membrane-Bound Protein Into The Membrane The Transmembrane Domain Controls Subcellular Localization Constitutes A Tail-Anchor Localizes In Early And Late Endosome Upon Blocking Of Apoptosis Must Localize To The Mitochondria To Induce Mitochondrial Outer Membrane Permeabilization And Apoptosis Isoform 2: Membrane
Alternative Antibody Names	Anti-Bcl-2-Related Ovarian Killer Protein antibody Anti-Hbok antibody Anti-Bcl-2-Like Protein 9 antibody Anti-Bcl2-L-9 antibody Anti-BOK antibody Anti-BCL2L9 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-BOK antibody (Internal) (STJ72368)