Anti-CD3e antibody [RIV9] (STJ16102628) STJ16102628 上海玉博生物科技有限公司

Anti-CD3e antibody [RIV9] (STJ16102628)

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产品名称：Anti-CD3e antibody [RIV9] (STJ16102628)
产品型号：STJ16102628
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CD3e antibody [RIV9] (STJ16102628)

产品描述

Host:	Mouse
Applications:	ELISA/FC/IF/IHC
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Mouse monoclonal antibody anti-CD3e is suitable for use in ELISA, Flow Cytometry, Immunofluorescence and Immunohistochemistry research applications.

Clonality:	Monoclonal
Clone ID:	RIV9
Conjugation:	Unconjugated
Isotype:	IgG3k
Formulation:	PBS with 0.02% Sodium Azide.
Purification:	Affinity purified from tissue culture.
Concentration:	Can be provided as 100 µg/mL, 500 µg/mL or 1mg/mL.
Dilution Range:	ELISA (solid phase: 0.1-100 µg/ml; tracer 0.001-100 µg/ml for 30 min at RT). Flow cytometry (0.5-1.0 µg/million cells in 0.1 ml). Immunofluorescence (0.5-1.0 µg/ml). Immunohistology (1.0-2.0 µg/ml for 30 min at RT; an antigen retrieval method for for
Storage Instruction:	Store for up to 1 year at 2-8°C upon receipt.

Gene Symbol:	CD3E
Gene ID:	916
Uniprot ID:	CD3E_HUMAN
Immunogen:	A BALB/c mouse was immunized with human peripheral lymphocytes. Fusion partner: P3-X63-Ag8.653.

Function	Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region.
Protein Name	T-Cell Surface Glycoprotein Cd3 Epsilon Chain T-Cell Surface Antigen T3/Leu-4 Epsilon Chain Cd Antigen Cd3e
Database Links	Reactome: R-HSA-198933 Reactome: R-HSA-202424 Reactome: R-HSA-202427 Reactome: R-HSA-202430 Reactome: R-HSA-202433 Reactome: R-HSA-389948
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein
Alternative Antibody Names	Anti-T-Cell Surface Glycoprotein Cd3 Epsilon Chain antibody Anti-T-Cell Surface Antigen T3/Leu-4 Epsilon Chain antibody Anti-Cd Antigen Cd3e antibody Anti-CD3E antibody Anti-T3E antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CD3e antibody [RIV9] (STJ16102628)