Anti-CD3E antibody [UCHT1] (STJA0002232) STJA0002232 上海玉博生物科技有限公司

Anti-CD3E antibody [UCHT1] (STJA0002232)

如果您对该产品感兴趣的话，可以
产品名称：Anti-CD3E antibody [UCHT1] (STJA0002232)
产品型号：STJA0002232
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CD3E antibody [UCHT1] (STJA0002232)

产品描述

Host:	Mouse
Applications:	Activ/Depletion/Inhibition/FC/IHC/WB
Reactivity:	Human
Note:	FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description:	Mouse monoclonal antibody anti-T-cell surface glycoprotein CD3 epsilon chain is suitable for use in Universal, Universal, Universal, Flow Cytometry, Immunohistochemistry and Western Blot research applications.

Clonality:	Monoclonal
Clone ID:	UCHT1
Conjugation:	Unconjugated
Isotype:	IgG1k
Formulation:	0.2 µm filtered in PBS, pH7.2. Azide Free (AF) /Low Endotoxin (LE) : Contains no stabilizers or preservatives. Endotoxin level is < 2 EU/mg (determined by LAL gel clotting assay.
Concentration:	0.5 mg/mL
Storage Instruction:	Store at 2-8°C. Do not freeze this product.

Gene Symbol:	CD3E
Gene ID:	916
Uniprot ID:	CD3E_HUMAN

Post Translational Modifications	Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8.
Function	Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region.
Protein Name	T-Cell Surface Glycoprotein Cd3 Epsilon Chain T-Cell Surface Antigen T3/Leu-4 Epsilon Chain Cd Antigen Cd3e
Database Links	Reactome: R-HSA-198933 Reactome: R-HSA-202424 Reactome: R-HSA-202427 Reactome: R-HSA-202430 Reactome: R-HSA-202433 Reactome: R-HSA-389948
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein
Alternative Antibody Names	Anti-T-Cell Surface Glycoprotein Cd3 Epsilon Chain antibody Anti-T-Cell Surface Antigen T3/Leu-4 Epsilon Chain antibody Anti-Cd Antigen Cd3e antibody Anti-CD3E antibody Anti-T3E antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

产品留言

标题

联系人

联系电话

内容

验证码

点击换一张

注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
2.如有必要,请您留下您的详细联系方式!

温馨提示：为规避购买风险，建议您在购买前务必确认供应商资质与产品质量。
免责申明：以上内容为注册会员自行发布，若信息的真实性、合法性存在争议，平台将会监督协助处理，欢迎举报

产品目录

产品资料

Anti-CD3E antibody [UCHT1] (STJA0002232)