Anti-CD3G antibody (131-181) {Biotin} (STJ500466) STJ500466-100 上海玉博生物科技有限公司

Anti-CD3G antibody (131-181) {Biotin} (STJ500466)

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产品名称：Anti-CD3G antibody (131-181) {Biotin} (STJ500466)
产品型号：STJ500466-100
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CD3G antibody (131-181) {Biotin} (STJ500466)

产品描述

Host:	Rabbit
Applications:	ELISA/IP/WB
Reactivity:	Human/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-CD3G (131-181) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Biotin
Isotype:	IgG
Purification:	Affinity Purified
Concentration:	0.55-0.75 µg/µl
Dilution Range:	WB: 1:500 DB: 1:10, 000 ELISA: 1:10, 000 IP: 1:150
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	CD3G
Gene ID:	917
Uniprot ID:	CD3G_HUMAN
Immunogen Region:	131-181
Immunogen:	Synthetic peptide taken within amino acid region 131-181 on human T-cell surface glycoprotein CD3 gamma protein.

Post Translational Modifications	Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8. Phosphorylated also by PKC.leading to the TCR complex down-regulation. Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8.
Function	Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition to this role of signal transduction in T-cell activation, CD3G plays an essential role in the dynamic regulation of TCR expression at the cell surface. Indeed, constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif present in CD3G.
Protein Name	T-Cell Surface Glycoprotein Cd3 Gamma Chain T-Cell Receptor T3 Gamma Chain Cd Antigen Cd3g
Database Links	Reactome: R-HSA-198933 Reactome: R-HSA-202424 Reactome: R-HSA-202427 Reactome: R-HSA-202430 Reactome: R-HSA-202433 Reactome: R-HSA-2029481 Reactome: R-HSA-2029482 Reactome: R-HSA-2029485 Reactome: R-HSA-389948 Reactome: R-HSA-8856825 Reactome: R-HSA-8856828 Reactome: R-HSA-9664323 Reactome: R-HSA-9664422
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein
Alternative Antibody Names	Anti-T-Cell Surface Glycoprotein Cd3 Gamma Chain antibody Anti-T-Cell Receptor T3 Gamma Chain antibody Anti-Cd Antigen Cd3g antibody Anti-CD3G antibody Anti-T3G antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CD3G antibody (131-181) {Biotin} (STJ500466)