Human NOTCH2NL (Notch2 N-Terminal Like Protein) Sandwich ELISA Kit (STJE0011020) STJE0011020 上海玉博生物科技有限公司

Human NOTCH2NL (Notch2 N-Terminal Like Protein) Sandwich ELISA Kit (STJE0011020)

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产品名称：Human NOTCH2NL (Notch2 N-Terminal Like Protein) Sandwich ELISA Kit (STJE0011020)
产品型号：STJE0011020
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human NOTCH2NL (Notch2 N-Terminal Like Protein) Sandwich ELISA Kit (STJE0011020)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.117ng/mL
Detection Limit:	0.312-20ng/mL
Short Description:	This NOTCH2NL Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	NOTCH2NLA
Gene ID:	388677
Uniprot ID:	NT2NA_HUMAN
Sample Type:	tissue homogenates, cell lysates or other biological fluids.

Tissue Specificity	Widely expressed with higher levels in leukocytes and lymph nodes. Expressed in radial glia neural stem cells during cortical development.
Post Translational Modifications	Cleaved by ELANE.
Function	Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway. Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes, thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production. Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect. Enhances Notch signaling pathway in a non-cell-autonomous manner via direct interaction with NOTCH2. Also promotes Notch signaling pathway in a cell-autonomous manner through inhibition of cis DLL1-NOTCH2 interactions, which promotes neuronal differentiation.
Protein Name	Notch Homolog 2 N-Terminal-Like Protein A Notch Homolog 2 N-Terminal-Like Protein
Database Links
Cellular Localisation	Secreted Cytoplasm
Alternative ELISA Names	Notch Homolog 2 N-Terminal-Like Protein A ELISA kit Notch Homolog 2 N-Terminal-Like Protein ELISA kit NOTCH2NLA ELISA kit N2N ELISA kit NOTCH2NL ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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