Human NPC2 (Niemann Pick Disease Type C2) Sandwich ELISA Kit Ready-To-Use (STJE0017414) STJE0017414 上海玉博生物科技有限公司

Human NPC2 (Niemann Pick Disease Type C2) Sandwich ELISA Kit Ready-To-Use (STJE0017414)

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产品名称：Human NPC2 (Niemann Pick Disease Type C2) Sandwich ELISA Kit Ready-To-Use (STJE0017414)
产品型号：STJE0017414
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human NPC2 (Niemann Pick Disease Type C2) Sandwich ELISA Kit Ready-To-Use (STJE0017414)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.31ng/mL
Detection Limit:	0.781-50ng/mL
Short Description:	This NPC2 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	3 hrs

Gene Symbol:	NPC2
Gene ID:	10577
Uniprot ID:	NPC2_HUMAN
Immunogen Region:	Ready-To-Use
Sample Type:	serum, plasma, tissue homogenates or other biological fluids.

Tissue Specificity	Detected in gallbladder bile. Detected in fibroblasts, kidney, liver, spleen, small intestine, placenta and testis (at protein level). Epididymis.
Post Translational Modifications
Function	Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. May bind and mobilize cholesterol that is associated with membranes. NPC2 binds cholesterol with a 1:1 stoichiometry. Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol and beta-sitosterol. The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport.
Protein Name	Npc Intracellular Cholesterol Transporter 2 Epididymal Secretory Protein E1 Human Epididymis-Specific Protein 1 He1 Niemann-Pick Disease Type C2 Protein
Database Links	Reactome: R-HSA-6798695 Reactome: R-HSA-8964038
Cellular Localisation	Secreted Endoplasmic Reticulum Lysosome Interaction With Cell-Surface M6pr Mediates Endocytosis And Targeting To Lysosomes
Alternative ELISA Names	Npc Intracellular Cholesterol Transporter 2 ELISA kit Epididymal Secretory Protein E1 ELISA kit Human Epididymis-Specific Protein 1 ELISA kit He1 ELISA kit Niemann-Pick Disease Type C2 Protein ELISA kit NPC2 ELISA kit HE1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human NPC2 (Niemann Pick Disease Type C2) Sandwich ELISA Kit Ready-To-Use (STJE0017414)