Anti-CD40LG antibody (113-261) (STJ23001) STJ23001 上海玉博生物科技有限公司

Anti-CD40LG antibody (113-261) (STJ23001)

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产品名称：Anti-CD40LG antibody (113-261) (STJ23001)
产品型号：STJ23001
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CD40LG antibody (113-261) (STJ23001)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-CD40L (113-261) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:100-1:500
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CD40LG
Gene ID:	959
Uniprot ID:	CD40L_HUMAN
Immunogen Region:	113-261
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 113-261 of human CD40L (NP_000065.1).
Immunogen Sequence:	MQKGDQNPQIAAHVISEASS KTTSVLQWAEKGYYTMSNNL VTLENGKQLTVKRQGLYYIY AQVTFCSNREASSQAPFIAS LCLKSPGRFERILLRAANTH SSAKPCGQQSIHLGGVFELQ PGASVFVNVTDPSQVSHGTG FTSFGLLKL

Tissue Specificity	Specifically expressed on activated CD4+ T-lymphocytes.
Post Translational Modifications	The soluble form derives from the membrane form by proteolytic processing. N-linked glycan is a mixture of high mannose and complex type. Glycan structure does not influence binding affinity to CD40. Not O-glycosylated.
Function	Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation. Induces the activation of NF-kappa-B. Induces the activation of kinases MAPK8 and PAK2 in T-cells. Induces tyrosine phosphorylation of isoform 3 of CD28. Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4. Involved in immunoglobulin class switching. CD40 ligand, soluble form: Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3.both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.
Protein Name	Cd40 Ligand Cd40-L T-Cell Antigen Gp39 Tnf-Related Activation Protein Trap Tumor Necrosis Factor Ligand Superfamily Member 5 Cd Antigen Cd154 Cleaved Into - Cd40 Ligand - Membrane Form - Cd40 Ligand - Soluble Form Scd40l
Database Links	Reactome: R-HSA-198933 Reactome: R-HSA-5668541 Reactome: R-HSA-5676594
Cellular Localisation	Cell Membrane Single-Pass Type Ii Membrane Protein Cell Surface Cd40 Ligand Soluble Form: Secreted Release Of Soluble Cd40l From Platelets Is Partially Regulated By Gp Iib/Iiia Actin Polymerization And A Matrix Metalloproteinases (Mmp) Inhibitor-Sensitive Pathway
Alternative Antibody Names	Anti-Cd40 Ligand antibody Anti-Cd40-L antibody Anti-T-Cell Antigen Gp39 antibody Anti-Tnf-Related Activation Protein antibody Anti-Trap antibody Anti-Tumor Necrosis Factor Ligand Superfamily Member 5 antibody Anti-Cd Antigen Cd154 Cleaved Into - Cd40 Ligand - Membrane Form - Cd40 Ligand - Soluble Form antibody Anti-Scd40l antibody Anti-CD40LG antibody Anti-CD40L antibody Anti-TNFSF5 antibody Anti-TRAP antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CD40LG antibody (113-261) (STJ23001)