Human NQO1 (NADH Dehydrogenase, Quinone 1) Sandwich ELISA Kit Ready-To-Use (STJE0017453) STJE0017453 上海玉博生物科技有限公司

Human NQO1 (NADH Dehydrogenase, Quinone 1) Sandwich ELISA Kit Ready-To-Use (STJE0017453)

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产品名称：Human NQO1 (NADH Dehydrogenase, Quinone 1) Sandwich ELISA Kit Ready-To-Use (STJE0017453)
产品型号：STJE0017453
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human NQO1 (NADH Dehydrogenase, Quinone 1) Sandwich ELISA Kit Ready-To-Use (STJE0017453)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.124ng/mL
Detection Limit:	0.312-20ng/mL
Short Description:	This NQO1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	3 hrs

Gene Symbol:	NQO1
Gene ID:	1728
Uniprot ID:	NQO1_HUMAN
Immunogen Region:	Ready-To-Use
Sample Type:	tissue homogenates, cell lysates or other biological fluids.

Tissue Specificity
Post Translational Modifications
Function	Flavin-containing quinone reductase that catalyzes two-electron reduction of quinones to hydroquinones using either NADH or NADPH as electron donors. In a ping-pong kinetic mechanism, the electrons are sequentially transferred from NAD(P)H to flavin cofactor and then from reduced flavin to the quinone, bypassing the formation of semiquinone and reactive oxygen species. Regulates cellular redox state primarily through quinone detoxification. Reduces components of plasma membrane redox system such as coenzyme Q and vitamin quinones, producing antioxidant hydroquinone forms. In the process may function as superoxide scavenger to prevent hydroquinone oxidation and facilitate excretion. Alternatively, can activate quinones and their derivatives by generating redox reactive hydroquinones with DNA cross-linking antitumor potential. Acts as a gatekeeper of the core 20S proteasome known to degrade proteins with unstructured regions. Upon oxidative stress, interacts with tumor suppressors TP53 and TP73 in a NADH-dependent way and inhibits their ubiquitin-independent degradation by the 20S proteasome.
Protein Name	Nad(Ph Dehydrogenase Quinone 1 Azoreductase Dt-Diaphorase Dtd Menadione Reductase Nad(Ph -Quinone Oxidoreductase 1 Phylloquinone Reductase Quinone Reductase 1 Qr1
Database Links	Reactome: R-HSA-350562 Reactome: R-HSA-9818027
Cellular Localisation	Cytoplasm Cytosol
Alternative ELISA Names	Nad(Ph Dehydrogenase Quinone 1 ELISA kit Azoreductase ELISA kit Dt-Diaphorase ELISA kit Dtd ELISA kit Menadione Reductase ELISA kit Nad(Ph -Quinone Oxidoreductase 1 ELISA kit Phylloquinone Reductase ELISA kit Quinone Reductase 1 ELISA kit Qr1 ELISA kit NQO1 ELISA kit DIA4 ELISA kit NMOR1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human NQO1 (NADH Dehydrogenase, Quinone 1) Sandwich ELISA Kit Ready-To-Use (STJE0017453)