Anti-CD44 antibody [156-3C11] (STJ16101870) STJ16101870 上海玉博生物科技有限公司

Anti-CD44 antibody [156-3C11] (STJ16101870)

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产品名称：Anti-CD44 antibody [156-3C11] (STJ16101870)
产品型号：STJ16101870
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CD44 antibody [156-3C11] (STJ16101870)

产品描述

Host:	Mouse
Applications:	FC/FUNC/WB/IF/IHC
Reactivity:	African Green Monkey/Baboon/Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Mouse monoclonal antibody anti-CD44 is suitable for use in Flow Cytometry, FUNC, Western Blot, Immunofluorescence and Immunohistochemistry research applications.

Clonality:	Monoclonal
Clone ID:	156-3C11
Conjugation:	Unconjugated
Isotype:	IgG2ak
Formulation:	PBS with 0.02% Sodium Azide.
Purification:	Affinity purified from tissue culture.
Concentration:	Can be provided as 100 µg/mL, 500 µg/mL or 1mg/mL.
Dilution Range:	Flow cytometry (0, 5-1, 0 µg/million cells in 0, 1 ml). Functional studies (0, 02-2, 0 µg/ml without azide). Immunoblotting (1-2 µg/ml). Immunofluorescence ( 1-2 µg/ml). Immunohistology (formalin-fixed: 1-2 µg/ml for 30 min at RT; requires boiling ti
Storage Instruction:	Store for up to 1 year at 2-8°C upon receipt.

Gene Symbol:	CD44
Gene ID:	960
Uniprot ID:	CD44_HUMAN
Immunogen:	A BALB/c mouse was immunized with stimulated human leucocytes. Fusion partner: NS-1.

Post Translational Modifications	Proteolytically cleaved in the extracellular matrix by specific proteinases (possibly MMPs) in several cell lines and tumors. N-glycosylated. O-glycosylated.contains chondroitin sulfate glycans which can be more or less sulfated and whose number may affect the accessibility of specific proteinases to their cleavage site(s). It is uncertain if O-glycosylation occurs on Thr-637 or Thr-638. Phosphorylated.activation of PKC results in the dephosphorylation of Ser-706 (constitutive phosphorylation site), and the phosphorylation of Ser-672.
Function	Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment. Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection. Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases. Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion.
Protein Name	Cd44 Antigen Cdw44 Epican Extracellular Matrix Receptor Iii Ecmr-Iii Gp90 Lymphocyte Homing/Adhesion Receptor Hutch-I Heparan Sulfate Proteoglycan Hermes Antigen Hyaluronate Receptor Phagocytic Glycoprotein 1 Pgp-1 Phagocytic Glycoprotein I Pgp-I Cd Antigen Cd44
Database Links	Reactome: R-HSA-1474228 Reactome: R-HSA-202733 Reactome: R-HSA-216083 Reactome: R-HSA-2160916 Reactome: R-HSA-6798695 Reactome: R-HSA-877300
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein Cell Projection Microvillus Secreted Colocalizes With Actin In Membrane Protrusions At Wounding Edges Co-Localizes With Rdx Ezr And Msn In Microvilli Localizes To Cholesterol-Rich Membrane-Bound Lipid Raft Domains
Alternative Antibody Names	Anti-Cd44 Antigen antibody Anti-Cdw44 antibody Anti-Epican antibody Anti-Extracellular Matrix Receptor Iii antibody Anti-Ecmr-Iii antibody Anti-Gp90 Lymphocyte Homing/Adhesion Receptor antibody Anti-Hutch-I antibody Anti-Heparan Sulfate Proteoglycan antibody Anti-Hermes Antigen antibody Anti-Hyaluronate Receptor antibody Anti-Phagocytic Glycoprotein 1 antibody Anti-Pgp-1 antibody Anti-Phagocytic Glycoprotein I antibody Anti-Pgp-I antibody Anti-Cd Antigen Cd44 antibody Anti-CD44 antibody Anti-LHR antibody Anti-MDU2 antibody Anti-MDU3 antibody Anti-MIC4 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CD44 antibody [156-3C11] (STJ16101870)