Anti-CD45 antibody [MEM-28] (STJ16100104) STJ16100104-01 上海玉博生物科技有限公司

Anti-CD45 antibody [MEM-28] (STJ16100104)

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产品名称：Anti-CD45 antibody [MEM-28] (STJ16100104)
产品型号：STJ16100104-01
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CD45 antibody [MEM-28] (STJ16100104)

产品描述

Host:	Mouse
Applications:	FC/IP/WB/IHC-P/ICC
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Mouse monoclonal antibody anti-CD45 is suitable for use in Flow Cytometry, Immunoprecipitation, Western Blot, Immunohistochemistry and Immunocytochemistry research applications.

Clonality:	Monoclonal
Clone ID:	MEM-28
Conjugation:	Unconjugated
Isotype:	IgG1
Formulation:	Phosphate buffered saline (PBS) solution with 15 mM sodium azide
Concentration:	1 mg/mL
Storage Instruction:	Store at 2-8°C upon receipt.

Gene Symbol:	PTPRC
Gene ID:	5788
Uniprot ID:	PTPRC_HUMAN
Immunogen:	Human thymocytes and T lymphocytes.

Tissue Specificity	Isoform 1: Detected in thymocytes. Isoform 2: Detected in thymocytes. Isoform 3: Detected in thymocytes. Isoform 4: Not detected in thymocytes. Isoform 5: Detected in thymocytes. Isoform 6: Not detected in thymocytes. Isoform 7: Detected in thymocytes. Isoform 8: Not detected in thymocytes.
Post Translational Modifications	Heavily N- and O-glycosylated.
Function	Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity. (Microbial infection) Acts as a receptor for human cytomegalovirus protein UL11 and mediates binding of UL11 to T-cells, leading to reduced induction of tyrosine phosphorylation of multiple signaling proteins upon T-cell receptor stimulation and impaired T-cell proliferation.
Protein Name	Receptor-Type Tyrosine-Protein Phosphatase C Leukocyte Common Antigen L-Ca T200 Cd Antigen Cd45
Database Links	Reactome: R-HSA-202427 Reactome: R-HSA-416700 Reactome: R-HSA-6798695
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein Membrane Raft Colocalized With Dpp4 In Membrane Rafts
Alternative Antibody Names	Anti-Receptor-Type Tyrosine-Protein Phosphatase C antibody Anti-Leukocyte Common Antigen antibody Anti-L-Ca antibody Anti-T200 antibody Anti-Cd Antigen Cd45 antibody Anti-PTPRC antibody Anti-CD45 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CD45 antibody [MEM-28] (STJ16100104)