Anti-CD45/PTPRC antibody [HI30] {ER780} (STJA0003931) STJA0003931 上海玉博生物科技有限公司

Anti-CD45/PTPRC antibody [HI30] {ER780} (STJA0003931)

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产品名称：Anti-CD45/PTPRC antibody [HI30] {ER780} (STJA0003931)
产品型号：STJA0003931
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CD45/PTPRC antibody [HI30] {ER780} (STJA0003931)

产品描述

Host:	Mouse
Applications:	FC
Reactivity:	Human
Note:	FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description:	Mouse monoclonal antibody anti-Receptor-type tyrosine-protein phosphatase C is suitable for use in Flow Cytometry research applications.

Clonality:	Monoclonal
Clone ID:	HI30
Conjugation:	ER780
Isotype:	IgG1k
Formulation:	PBS with 0.05% Proclin300, 1% BSA
Storage Instruction:	Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product.

Gene Symbol:	PTPRC
Gene ID:	5788
Uniprot ID:	PTPRC_HUMAN

Tissue Specificity	Isoform 1: Detected in thymocytes. Isoform 2: Detected in thymocytes. Isoform 3: Detected in thymocytes. Isoform 4: Not detected in thymocytes. Isoform 5: Detected in thymocytes. Isoform 6: Not detected in thymocytes. Isoform 7: Detected in thymocytes. Isoform 8: Not detected in thymocytes.
Post Translational Modifications	Heavily N- and O-glycosylated.
Function	Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity. (Microbial infection) Acts as a receptor for human cytomegalovirus protein UL11 and mediates binding of UL11 to T-cells, leading to reduced induction of tyrosine phosphorylation of multiple signaling proteins upon T-cell receptor stimulation and impaired T-cell proliferation.
Protein Name	Receptor-Type Tyrosine-Protein Phosphatase C Leukocyte Common Antigen L-Ca T200 Cd Antigen Cd45
Database Links	Reactome: R-HSA-202427 Reactome: R-HSA-416700 Reactome: R-HSA-6798695
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein Membrane Raft Colocalized With Dpp4 In Membrane Rafts
Alternative Antibody Names	Anti-Receptor-Type Tyrosine-Protein Phosphatase C antibody Anti-Leukocyte Common Antigen antibody Anti-L-Ca antibody Anti-T200 antibody Anti-Cd Antigen Cd45 antibody Anti-PTPRC antibody Anti-CD45 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CD45/PTPRC antibody [HI30] {ER780} (STJA0003931)