Anti-BRSK1 antibody (310-510) (STJ119351) STJ119351 上海玉博生物科技有限公司

Anti-BRSK1 antibody (310-510) (STJ119351)

如果您对该产品感兴趣的话，可以
产品名称：Anti-BRSK1 antibody (310-510) (STJ119351)
产品型号：STJ119351
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-BRSK1 antibody (310-510) (STJ119351)

产品描述

Host:	Rabbit
Applications:	WB/IHC
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-BRSK1 (310-510) is suitable for use in Western Blot and Immunohistochemistry research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000 IHC-P 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	BRSK1
Gene ID:	84446
Uniprot ID:	BRSK1_HUMAN
Immunogen Region:	310-510
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 310-510 of human BRSK1 (NP_115806.1).
Immunogen Sequence:	PSNGELDPDVLESMASLGCF RDRERLHRELRSEEENQEKM IYYLLLDRKERYPSCEDQDL PPRNDVDPPRKRVDSPMLSR HGKRRPERKSMEVLSITDAG GGGSPVPTRRALEMAQHSQR SRSVSGASTGLSSSPLSSPR SPVFSFSPEPGAGDEARGGG SPTSKTQTLPSRGPRGGGAG EQPPPPSARSTPLPGPPGSP R

Tissue Specificity	Widely expressed, with highest levels in brain and testis. Protein levels remain constant throughout the cell cycle.
Post Translational Modifications	Phosphorylated at Thr-189 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Not phosphorylated at Thr-189 by CaMKK2. In contrast, it is phosphorylated and activated by CaMKK1. May be inactivated via dephosphorylation of Thr-189 by PP2C.
Function	Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C.
Protein Name	Serine/Threonine-Protein Kinase Brsk1 Brain-Selective Kinase 1 Brain-Specific Serine/Threonine-Protein Kinase 1 Br Serine/Threonine-Protein Kinase 1 Serine/Threonine-Protein Kinase Sad-B Synapses Of Amphids Defective Homolog 1 Sad1 Homolog Hsad1
Cellular Localisation	Cytoplasm Nucleus Cytoskeleton Microtubule Organizing Center Centrosome Synapse Presynaptic Active Zone Cytoplasmic Vesicle Secretory Vesicle Synaptic Vesicle Nuclear In The Absence Of Dna Damage Translocated To The Nucleus In Response To Uv- Or Mms-Induced Dna Damage
Alternative Antibody Names	Anti-Serine/Threonine-Protein Kinase Brsk1 antibody Anti-Brain-Selective Kinase 1 antibody Anti-Brain-Specific Serine/Threonine-Protein Kinase 1 antibody Anti-Br Serine/Threonine-Protein Kinase 1 antibody Anti-Serine/Threonine-Protein Kinase Sad-B antibody Anti-Synapses Of Amphids Defective Homolog 1 antibody Anti-Sad1 Homolog antibody Anti-Hsad1 antibody Anti-BRSK1 antibody Anti-KIAA1811 antibody Anti-SAD1 antibody Anti-SADB antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

产品留言

标题

联系人

联系电话

内容

验证码

点击换一张

注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
2.如有必要,请您留下您的详细联系方式!

温馨提示：为规避购买风险，建议您在购买前务必确认供应商资质与产品质量。
免责申明：以上内容为注册会员自行发布，若信息的真实性、合法性存在争议，平台将会监督协助处理，欢迎举报

产品目录

产品资料

Anti-BRSK1 antibody (310-510) (STJ119351)