Anti-BRSK2 antibody (200-300) (STJ11102836) STJ11102836 上海玉博生物科技有限公司

Anti-BRSK2 antibody (200-300) (STJ11102836)

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产品名称：Anti-BRSK2 antibody (200-300) (STJ11102836)
产品型号：STJ11102836
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-BRSK2 antibody (200-300) (STJ11102836)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-BRSK2 (200-300) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	BRSK2
Gene ID:	9024
Uniprot ID:	BRSK2_HUMAN
Immunogen Region:	200-300
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 200-300 of human BRSK2 (NP_001243556.1).
Immunogen Sequence:	WSCGVILFALLVGALPFDDD NLRQLLEKVKRGVFHMPHFI PPDCQSLLRGMIEVDAARRL TLEHIQKHIWYIGGKNEPEP EQPIPRKVQIRSLPSLEDID P

Tissue Specificity	Detected in pancreas islets (at protein level).
Post Translational Modifications	Phosphorylated at Thr-174 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Not phosphorylated at Thr-174 by CaMKK2. In contrast, it is phosphorylated and activated by CaMKK1. May be inactivated via dephosphorylation of Thr-174 by PP2C. Phosphorylated at Thr-260 by PKA. Phosphorylation at Thr-260 by PKA was not observed in another study, but this may reflect differences in the experimental approach. Phosphorylation at Thr-260 seems to play a role in the regulation of insulin secretion. Polyubiquitinated by the APC complex in conjunction with FZR1, leading to its proteasomal degradation. Targeted for proteasomal degradation by interaction with COPS5. BRSK2 levels change during the cell cycle. BRSK2 levels are low at the G1/S boundary and gradually increase as cells progress into G2 phase. BRSK2 levels decrease rapidly at the end of mitosis.
Function	Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr-174 can inhibit insulin secretion, BRSK2 phosphorylated at Thr-260 can promote insulin secretion. Regulates reorganization of the actin cytoskeleton. May play a role in the apoptotic response triggered by endoplasmic reticulum (ER) stress.
Protein Name	Serine/Threonine-Protein Kinase Brsk2 Brain-Selective Kinase 2 Brain-Specific Serine/Threonine-Protein Kinase 2 Br Serine/Threonine-Protein Kinase 2 Serine/Threonine-Protein Kinase 29 Serine/Threonine-Protein Kinase Sad-A
Cellular Localisation	Cytoplasm Cytoskeleton Microtubule Organizing Center Centrosome Perinuclear Region Endoplasmic Reticulum Detected At Centrosomes During Mitosis Localizes To The Endoplasmic Reticulum In Response To Stress Caused By Tunicamycin
Alternative Antibody Names	Anti-Serine/Threonine-Protein Kinase Brsk2 antibody Anti-Brain-Selective Kinase 2 antibody Anti-Brain-Specific Serine/Threonine-Protein Kinase 2 antibody Anti-Br Serine/Threonine-Protein Kinase 2 antibody Anti-Serine/Threonine-Protein Kinase 29 antibody Anti-Serine/Threonine-Protein Kinase Sad-A antibody Anti-BRSK2 antibody Anti-C11orf7 antibody Anti-PEN11B antibody Anti-SADA antibody Anti-STK29 antibody Anti-HUSSY-12 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-BRSK2 antibody (200-300) (STJ11102836)