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> Human PLCg1 (Phospholipase C Gamma 1) Sandwich ELISA Kit Ready-To-Use (STJE0017925)

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Human PLCg1 (Phospholipase C Gamma 1) Sandwich ELISA Kit Ready-To-Use (STJE0017925)

Human PLCg1 (Phospholipase C Gamma 1) Sandwich ELISA Kit Ready-To-Use (STJE0017925)
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  • 产品名称:Human PLCg1 (Phospholipase C Gamma 1) Sandwich ELISA Kit Ready-To-Use (STJE0017925)
  • 产品型号:STJE0017925
  • 产品展商:ST john's laboratory
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简单介绍
Human PLCg1 (Phospholipase C Gamma 1) Sandwich ELISA Kit Ready-To-Use (STJE0017925)
产品描述
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.068ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This PLCg1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: PLCG1
Gene ID: 5335
Uniprot ID: PLCG1_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity
Post Translational Modifications Tyrosine phosphorylated in response to signaling via activated FLT3, KIT and PDGFRA. Tyrosine phosphorylated by activated FGFR1, FGFR2, FGFR3 and FGFR4. Tyrosine phosphorylated by activated FLT1 and KDR. Tyrosine phosphorylated by activated PDGFRB. The receptor-mediated activation of PLCG1 involves its phosphorylation by tyrosine kinases, in response to ligation of a variety of growth factor receptors and immune system receptors. For instance, SYK phosphorylates and activates PLCG1 in response to ligation of the B-cell receptor. May be dephosphorylated by PTPRJ. Phosphorylated by ITK and TXK on Tyr-783 upon TCR activation in T-cells. Ubiquitinated by CBLB in activated T-cells.
Function Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, EGFR, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration.
Protein Name 1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Gamma-1
Plc-148
Phosphoinositide Phospholipase C-Gamma-1
Phospholipase C-Ii
Plc-Ii
Phospholipase C-Gamma-1
Plc-Gamma-1
Database Links Reactome: R-HSA-1169408
Reactome: R-HSA-1236382
Reactome: R-HSA-1251932
Reactome: R-HSA-1489509
Reactome: R-HSA-167021
Reactome: R-HSA-1855204
Reactome: R-HSA-186763
Reactome: R-HSA-201556
Reactome: R-HSA-202433
Reactome: R-HSA-2029485
Reactome: R-HSA-210990
Reactome: R-HSA-212718
Reactome: R-HSA-2424491
Reactome: R-HSA-2871796
Reactome: R-HSA-2871809
Reactome: R-HSA-418890
Reactome: R-HSA-5218921
Reactome: R-HSA-5637810
Reactome: R-HSA-5654219
Reactome: R-HSA-5654221
Reactome: R-HSA-5654227
Reactome: R-HSA-5654228
Reactome: R-HSA-5655253
Reactome: R-HSA-5655291
Reactome: R-HSA-5655302
Reactome: R-HSA-5655332
Reactome: R-HSA-8853659
Reactome: R-HSA-9026527
Reactome: R-HSA-9027277
Reactome: R-HSA-9034793
Reactome: R-HSA-9664323
Reactome: R-HSA-9664565
Reactome: R-HSA-9665348
Reactome: R-HSA-9665686
Reactome: R-HSA-9725370
Cellular Localisation Cell Projection
Lamellipodium
Ruffle
Rapidly Redistributed To Ruffles And Lamellipodia Structures In Response To Epidermal Growth Factor (Egf) Treatment
Alternative ELISA Names 1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Gamma-1 ELISA kit
Plc-148 ELISA kit
Phosphoinositide Phospholipase C-Gamma-1 ELISA kit
Phospholipase C-Ii ELISA kit
Plc-Ii ELISA kit
Phospholipase C-Gamma-1 ELISA kit
Plc-Gamma-1 ELISA kit
PLCG1 ELISA kit
PLC1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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