Human PP2Aa (Serine/Threonine-Protein Phosphatase 2A 56 kDa Regulatory Subunit Alpha Isoform) Sandwich ELISA Kit Ready-To-Use (STJE0017987) STJE0017987 上海玉博生物科技有限公司

Human PP2Aa (Serine/Threonine-Protein Phosphatase 2A 56 kDa Regulatory Subunit Alpha Isoform) Sandwich ELISA Kit Ready-To-Use (STJE0017987)

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产品名称：Human PP2Aa (Serine/Threonine-Protein Phosphatase 2A 56 kDa Regulatory Subunit Alpha Isoform) Sandwich ELISA Kit Ready-To-Use (STJE0017987)
产品型号：STJE0017987
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human PP2Aa (Serine/Threonine-Protein Phosphatase 2A 56 kDa Regulatory Subunit Alpha Isoform) Sandwich ELISA Kit Ready-To-Use (STJE0017987)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	30.9pg/mL
Detection Limit:	78.1-5000pg/mL
Short Description:	This PP2Aa Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	3 hrs

Gene Symbol:	PPP2R1A
Gene ID:	5518
Uniprot ID:	2AAA_HUMAN
Immunogen Region:	Ready-To-Use
Sample Type:	serum, plasma, tissue homogenates or other biological fluids.

Tissue Specificity
Post Translational Modifications
Function	The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT. Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis. Together with RACK1 adapter, mediates dephosphorylation of AKT1 at 'Ser-473', preventing AKT1 activation and AKT-mTOR signaling pathway. Dephosphorylation of AKT1 is essential for regulatory T-cells (Treg) homeostasis and stability.
Protein Name	Serine/Threonine-Protein Phosphatase 2a 65 Kda Regulatory Subunit A Alpha Isoform Medium Tumor Antigen-Associated 61 Kda Protein Pp2a Subunit A Isoform Pr65-Alpha Pp2a Subunit A Isoform R1-Alpha
Database Links	Reactome: R-HSA-113501 Reactome: R-HSA-1295596 Reactome: R-HSA-141444 Reactome: R-HSA-163685 Reactome: R-HSA-163767 Reactome: R-HSA-180024 Reactome: R-HSA-195253 Reactome: R-HSA-196299 Reactome: R-HSA-198753 Reactome: R-HSA-202670 Reactome: R-HSA-2465910 Reactome: R-HSA-2467813 Reactome: R-HSA-2500257 Reactome: R-HSA-2565942 Reactome: R-HSA-2995383 Reactome: R-HSA-380259 Reactome: R-HSA-380270 Reactome: R-HSA-380284 Reactome: R-HSA-380320 Reactome: R-HSA-389513 Reactome: R-HSA-432142 Reactome: R-HSA-4641262 Reactome: R-HSA-5339716 Reactome: R-HSA-5358747 Reactome: R-HSA-5358749 Reactome: R-HSA-5358751 Reactome: R-HSA-5358752 Reactome: R-HSA-5467337 Reactome: R-HSA-5467340 Reactome: R-HSA-5467348 Reactome: R-HSA-5620912 Reactome: R-HSA-5663220 Reactome: R-HSA-5673000 Reactome: R-HSA-5675221 Reactome: R-HSA-6804757 Reactome: R-HSA-6811558 Reactome: R-HSA-68877 Reactome: R-HSA-69231 Reactome: R-HSA-69273 Reactome: R-HSA-8854518 Reactome: R-HSA-9634600 Reactome: R-HSA-9648025 Reactome: R-HSA-975957
Cellular Localisation	Cytoplasm Nucleus Chromosome Centromere Lateral Cell Membrane Cell Projection Dendrite Centromeric Localization Requires The Presence Of Bub1
Alternative ELISA Names	Serine/Threonine-Protein Phosphatase 2a 65 Kda Regulatory Subunit A Alpha Isoform ELISA kit Medium Tumor Antigen-Associated 61 Kda Protein ELISA kit Pp2a Subunit A Isoform Pr65-Alpha ELISA kit Pp2a Subunit A Isoform R1-Alpha ELISA kit PPP2R1A ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human PP2Aa (Serine/Threonine-Protein Phosphatase 2A 56 kDa Regulatory Subunit Alpha Isoform) Sandwich ELISA Kit Ready-To-Use (STJE0017987)